Rapid fabrication of microneedles using magnetorheological drawing lithography

Zhipeng Chen,Lei Ren, Jiyu Li, Lebin Yao, Yan Chen, Bin Liu, Lelun Jiang*

Acta Biomaterialia Volume 65, January 2018, Pages 283-291

原文链接：https://doi.org/10.1016/j.actbio.2017.10.030

Abstract

Microneedles are micron-sized needles that are widely applied in biomedical fields owing to their painless, minimally invasive, and convenient operation. However, most microneedle fabrication approaches are costly, time consuming, involve multiple steps, and require expensive equipment. In this study, we present a novel magnetorheological drawing lithography (MRDL) method to efficiently fabricate microneedle, bio-inspired microneedle, and molding-free microneedle array. With the assistance of an external magnetic field, the 3D structure of a microneedle can be directly drawn from a droplet of curable magnetorheological fluid. The formation process of a microneedle consists of two key stages, elasto-capillary self-thinning and magneto-capillary self-shrinking, which greatly affect the microneedle height and tip radius. Penetration and fracture tests demonstrated that the microneedle had sufficient strength and toughness for skin penetration. Microneedle arrays and a bio-inspired microneedle were also fabricated, which further demonstrated the versatility and flexibility of the MRDL method.

Keywords: Microneedle array; Bio-inspired microneedle; Magnetorheological fluid; Self-assembly; Drawing lithography