Nanostructured Surface with Tunable Contact Angle Hysteresis for Constructing In Vitro Tumor Model

Kang Sun, Mingliang Yang, Yue Xu, Lelun Jiang, Rong Song, Yang Liu, Qing Jiang, and Chao Zhang*

Journal of Nanomaterials Volume 2016, Article ID 8275915, 5 pages

原文链接：http://dx.doi.org/10.1155/2016/8275915

Abstract

Contact angle hysteresis (CAH) is an important phenomenon in surface chemistry. In this paper, we fabricated nanostructured substrates and investigated the relationship between roughness and CAH. We demonstrated that by patterning well-tuned CAH in superhydrophobic background, we can pattern droplets with controlled sizes. We further showed that our system could be used in fabricating complex hydrogel architecture, allowing coculture of different types of cells in three-dimensional way. This CAH-based patterning strategy would provide in vitro models for tissue engineering and drug delivery.