工作经历（Working Experience）

2023.06-至今：中山大学，生物医学工程学院，副教授

2020.05-2023.05：中山大学，生物医学工程学院，“百人计划”助理教授

2015.05-2020.04：华中科技大学，生物医学工程系，博士后

 

教育经历（Education）

2009.09-2015.03：华中科技大学，生物医学工程，博士

2011.09-2013.03：麦吉尔大学，高分子物理，CSC公派联合培养博士生

2005.09-2009.06：华中科技大学，生物技术，学士

 

研究方向（Research Interest）

细胞仿生培养，先进生物制造（生物组装、生物打印），骨/软骨组织微环境工程，骨/软骨疾病（炎症、肿瘤）的体外模型及精准治疗

 

科研项目(Research Funding)

  1. 国家自然科学基金面上项目，基于免疫栓塞改良肿瘤微环境的原位CAR-T方法与机制研究，2022-2025，主持。（58万元）
  2. 广东省自然科学基金面上项目，三维工程组织的声学生物组装构建与细胞调控机理研究，2021-2023，主持。（10万）
  3. 出站博士后来深科研资助，细胞三维培养与类组织/器官工程，2021-2023，主持。（30万）
  4. 国家自然科学基金青年项目，三维工程组织的动态模块组装与细胞调控机理研究，2019-2021，主持，已结题。（25万元）
  5. 中国博士后科学基金面上项目（一等资助），靶向肿瘤酸性微环境的智能复合胶束系统，2015-2017，主持，已结题。（8万元）

 

论著（Publications）

代表论文（*为通讯作者，#为同等贡献作者）

  1. Dou, H., Wang, S., Hu, J., Song, J., Zhang, C., Wang, J., Xiao, L.* (2023). Osteoarthritis models: From animals to tissue engineering. Journal of Tissue Engineering, 14, 1-23. 
  2. Xiao, L., Xu, W., Huang, L.,* Liu, J., Yang, G.* (2023). Nanocomposite pastes of gelatin and cyclodextrin-grafted chitosan nanoparticles as potential postoperative tumor therapy. Advanced Composites and Hybrid Materials, 6(1): 15.
  3. Huang, Y., Li, X., Poudel, A. J.. Zhang, W., Xiao, L.* (2022). Hydrogel-based bioinks for 3D bioprinting articular cartilage: A comprehensive review with focus on mechanical reinforcement. Applied Materials Today, 29: 101668.
  4. Xu, W., Zhu, J., Hu, J., Xiao, L.* (2022). Engineering the biomechanical microenvironment of chondrocytes towards articular cartilage tissue engineering. Life Sciences, 309: 121043.
  5. Liu, L., Ji, X., Mao, L., Wang, L., Chen, K., Shi, Z., Ahmed, A. A. Q., Thomas, S., Vasilievich, R. V., Xiao, L.*, Li, X.*, Yang, G.* (2022). Hierarchical-structured bacterial cellulose/potato starch tubes as potential small-diameter vascular grafts. Carbohydrate Polymers, 281, 119034.
  6. Li, X., Ji, X., Chen, K., Ullah, M. W., Li, B., Cao, J., Xiao, L.*, Xiao, J.*, Yang, G.* (2021). Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation. Bioactive materials, 6(7), 2105-2119.
  7. Ahmed, A. A. Q., Qi, F., Zheng, R., Xiao, L.*, Abdalla, A. M., Mao, L., Bakadia, B. M., Liu, L., Atta, O. M., Li, X., Shi, Z., Yang, G.* (2021). The impact of ExHp-CD (outer membrane vesicles) released from Helicobacter pylori SS1 on macrophage RAW 264.7 cells and their immunogenic potential. Life Sciences, 279, 119644.
  8. Ahmed, A. A. Q., Zheng, R., Abdalla, A. M., Bakadia, B. M., Qi, F., Xiao, L.*, Atta, O. M., Mao, L., Yang, G.* (2021). Heterogeneous populations of outer membrane vesicles released from Helicobacter pylori SS1 with distinct biological properties. Engineered Science, 15, 148-165.
  9. Abdalla, A. M., Xiao, L.*, Yu, M., Huang, L., Gauthier, M., Ouyang, C., Yang, G.*(2020) Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer. Advanced Science, 1903164.
  10. Xiao, L., Poudel, A. J., Huang, L., Wang, Y., Abdalla, A. M., Yang, G.*(2020). Nanocellulose hyperfine network achieves sustained release of berberine hydrochloride solubilized with β-cyclodextrin for potential anti-infection oral administration. International Journal of Biological Macromolecules, 153, 633-640.
  11. Huang, L., Abdalla, A. M., Xiao, L.*, Yang, G.* (2020). Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation. International Journal of Molecular Sciences, 21, 1895.
  12. Tiatou, S., Lamboni, L., Xiao, L.*, Yang, G.* (2018). Cancer hallmarks and malignancy features: Gateway for improved targeted drug delivery. Biotechnology Advances, 36,1928-1945.
  13. Poudel, A. J., He, F., Huang, L., Xiao, L.*, Yang, G.* (2018). Supramolecular Hydrogels Based on Poly (ethylene glycol)-Poly (lactic acid) Block Copolymer Micelles and α-Cyclodextrin for Potential Injectable Drug Delivery System. Carbohydrate Polymers,194,69-79.
  14. Huang, L.#, Xiao, L.#, Poudel, A. J., Gauthier, M., & Yang, G.* (2018). Porous Chitosan Microspheres as Microcarriers for 3D Cell Culture. Carbohydrate Polymers, 202, 611-620.
  15. Abdalla, A. M.#, Xiao, L.#, Ullah, M. W., Yu, M., Ouyang, C., & Yang, G.* (2018). Current Challenges of Cancer Anti-angiogenic Therapy and the Promise of Nanotherapeutics. Theranostics, 8(2), 533.
  16. Xiao, L., Huang, L., Moingeon, F., Gauthier, M.*, & Yang, G.* (2017). pH-Responsive Poly (Ethylene Glycol)-block-Polylactide Micelles for Tumor-Targeted Drug Delivery. Biomacromolecules, 18(9), 2711-2722.
  17. Xiao, L., Vyhnalkova, R., Sailer, M., Yang, G., Barrett, C. J., & Eisenberg, A.* (2014). Planar multilayer assemblies containing block copolymer aggregates. Langmuir, 30(3), 891-899.
  18. Vyhnalkova, R.#, Xiao, L.#, Yang, G., & Eisenberg, A.* (2014). Spherical blackberry-type capsules containing block copolymer aggregates. Langmuir, 30(8), 2188-2195.
  19. Xiao, L., Mai, Y., He, F., Yu, L., Zhang, L., Tang, H., & Yang, G.* (2012). Bio-based green composites with high performance from poly (lactic acid) and surface-modified microcrystalline cellulose. Journal of Materials Chemistry, 22(31), 15732-15739.

 

书稿/章节

  1. Yang, G., Xiao, L. (co-editor), Lamboni, L. Bioinspired Materials Science and Engineering, ISBN: 978-1119390329, John Wiley& Sons, Inc, 2018.
  2. Ahmed, A. A. Q., Xiao, L.*, McKay, T. J. M., Yang, G*. Green Metal-Based Nanoparticles Synthesized Using Medicinal Plants and Plant Phytochemicals against Multidrug-Resistant Staphylococcus aureus. In Green Synthesis in Nanomedicine and Human Health. CRC Press, 2021, pp. 181–246.
  3. Xiao, L., Wang, B., Yang, G.*, Gauthier, M. Poly(lactic acid)-based biomaterials: synthesis, modification and applications, Biomedical Science, Engineering and Technology, InTech Publisher, 2012, pp. 247–282.
  4. Xiao, L., Huang, L., Liu, L., Yang, G.*. “Self-assembly of Polylactic Acid-based Amphiphilic Block Copolymers and Their Application in the Biomedical Field”, Bioinspired Materials Science and Engineering, John Wiley& Sons, Inc, 2018. pp. 119–128.

 

专利（Patents）

  1. 肖林，豆红媛，吴钊英，朱静，张超. 骨性关节炎模型及使用方法，申请号：202310696986X.
  2. 肖林，朱应欧，朱静，吴钊英，张超. 一种双层图案化界面结构的构建方法及其应用，申请号：202310691611.4.  
  3. 肖林，朱静，罗秋陈，张超. 一种基于法拉第波的高活性软骨组织的构建方法，申请号：202210218849.0.
  4. 肖林，徐维畅，朱静，张超. 一种用于骨关节炎治疗的壳聚糖/明胶复合膏体材料及其制备方法和应用，申请号：2022116257462.
  5. 肖林，朱静，张超. 三维多层结构的制备方法，专利号：202210218849.0. 
  6. 杨光，黄丽霞，肖林，郑瑞珠，刘海清. 一种多孔壳聚糖微载体及其制备方法和应用，专利号：201711320768.7.
  7. 杨光，肖林，周凤，黄丽霞，刘莉. 一种壳聚糖和明胶的超分子水凝胶及其制备方法与应用，专利号：201810601686.8.
  8. 杨光，肖林，黄丽霞，付丽娜，刘莉. 一种原位涂层修饰细菌纤维素水凝胶及其制备方法，专利号：201810930259.4.

 

荣誉奖项

中山大学优秀班主任，2023

中山大学优秀本科毕业论文（指导老师），2022

第六届全国大学生生物医学工程创新设计竞赛一等奖（指导老师），2021

第九届中山大学教师教学竞赛二等奖，2021

 

兼职与服务（Public Service）

深圳市高层次人才，国家自然科学基金通讯评议人，深圳市科创委入库科技专家，广东省生物医学工程学会植入器械与先进制造分会常务委员，深圳市生物医学工程学会会员等。Acta Biomaterialia, International Journal of Bioprinting, Colloids and surfaces B: Biointerfaces,《中国组织工程研究》等期刊审稿人。