刘杰

2014.06-现在：中山大学，副教授

2010.10-2014.05：中山大学，“百人计划”讲师

2007.10-2009.10：美国耶鲁大学，生物医学工程专业博士

2007.01-2010.10：华中科技大学，生命学院生物医学工程专业博士



学科方向

生物医学工程专业，生物材料与靶向药物输送方向，具体为：

1. 靶向纳米药物/基因载体系统：针对恶性肿瘤治疗，通过功能化生物材料的合成、载体构建以及靶向修饰为手段，开发系列能够用于癌症治疗的纳米药物、基因输送体系，为肿瘤的靶向治疗提供新的方法和策略；

2. 多功能纳米诊疗一体化生物材料：结合超声、磁共振、CT等技术手段，开发能够用于肿瘤及其他重大疾病诊断和治疗一体化的多功能纳米生物材料。

 
科研项目

先后主持国家自然科学基金、广东省自然科学基金等10余个项目，包括：

1.  广东省自然科学基金研究团队项目，多功能输送核酸的纳米体系，2015-2018，300万，五个核心成员之一

2.  广东省科技计划国际合作项目，新型药物输送载体材料的酶催化合成及其应用研究，2015-2017，50万

3.  广东省科技计划项目，“广东特支计划”科技创新青年拔尖人才，2015-2018，30万

4.  国家自然科学基金青年科学基金项目，酶催化合成新型可降解氨基聚酯作为基因传递系统的研究，2012-2014，25万

5.  广州市珠江科技新星专项，新型双靶向抗肿瘤纳米控释载体的构建及其应用研究，2012- 2015，30万

6.  中山大学中央高校基本科研业务费，结肠生物黏附型靶向纳米载药微粒的研究，2012- 2015，15万

7.  教育部博士点基金，靶向氨基聚酯基因载体的酶促合成及其功能研究，2012-2014，4万

8.  广东省自然科学基金，酶催化合成新型氨基聚酯用于靶向基因传递的研究， 2011-2013，3万

9.  广东高校优秀青年创新人才培养项目，新型靶向氨基聚酯基因载体的酶催化合成及性能研究，2012-2013，3万

10.  广东省科技计划项目，新型靶向纳米抗肿瘤药物制剂及其产业化关键技术研究， 2014-2015，10万（co-PI）

 
论著发明

[1]. Jiangbing Zhou, Jie Liu(共同第一作者), Christopher J. Cheng, Toral R. Patel, Caroline E.Weller, Joseph M. Piepmeier, Zhaozhong Jiang and W. Mark Saltzman*. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nature Materials 2012, 11: 82-90 (SCI, IF=36.4)

[2]. Zhe Yang, Huiyan Luo, Zhong Cao, Ya Chen, Jinbiao Gao, Yingqin Li, Qing Jiang, Ruihua Xu* and Jie Liu*，Dual-targeting hybrid nanoparticles for the delivery of SN38 to Her2 and CD44 overexpressed human gastric cancer, Nanoscale, 2016, 8, 11543–11558 (SCI, IF=7.760)

[3]. Ya Chen, Yingqin Li, Jinbiao Gao, Zhong Cao, Qing Jiang, Jie Liu*(共同通讯作者), and Zhaozhong Jiang*. Enzymatic PEGylated Poly(lactone-co-β-amino ester) Nanoparticles as Biodegradable, Biocompatible and Stable Vectors for Gene Delivery. ACS Applied Materials & Interfaces, 2016, 8(1): 490-501 (SCI, IF=6.723)

[4]. Di Gao, Ming Xu, Zhong Cao, Jinbiao Gao, Ya Chen, Yingqin Li, Zhe Yang, Xiaoyan Xie, Qing Jiang, Wei Wang, Jie Liu* (通讯作者). Ultrasound-triggered phase transition cationic nanodroplets for enhanced gene delivery. ACS Applied Materials & Interfaces, 2015, 7(24):13524-37 (SCI, IF=5.900)

[5]. Bo Liu, Xiaofang Zhang, Ya Chen, Zhicheng Yao, Zhe Yang, Di Gao, Qing Jiang, Jie Liu* (共同通讯作者) and Zhaozhong Jiang*. Enzymatic synthesis of poly(ω-pentadecalactoneco- butylene-co-3,3’-dithiodipropionate) copolyesters and self-assembly of the PEGylated copolymer micelles as redox-responsive nanocarriers for doxorubicin delivery. Polymer Chemistry, 2015, 6: 1997-2010 (SCI, IF=5.368)

[6]. Zhe Yang, Di Gao, Zhong Cao, Chao Zhang, Du Cheng, Jie Liu* (共同通讯作者) and Xintao Shuai*. Drug and gene co-delivery systems for cancer treatment. Biomaterials Science, 2015, 3, 1035–1049 (SCI, IF=3.614)

[7]. Zhe Yang, Wenxin Tang, Xingen Luo, Xiaofang Zhang, Chao Zhang, Hao Li, Di Gao, Huiyan Luo, Qing Jiang, and Jie Liu (通讯作者). Dual-Ligand Modified Polymer-Lipid Hybrid Nanoparticles for Docetaxel Targeting Delivery to Her2/neu Over-expressed Human Breast Cancer Cells. Journal of Biomedical Nanotechnology, 2015, 11: 1401-1417 (SCI, IF=7.578)

[8]. Zhe Yang, Zhaozhong Jiang, Zhong Cao, Chao Zhang, Di Gao, Xingen Luo, Xiaofang Zhang, Huiyan Luo, Qing Jiang and Jie Liu (通讯作者). Multifunctional non-viral gene vectors with enhanced stability, improved cellular and nuclear uptake capability, and increased transfection efficiency. Nanoscale, 2014, 6: 10193–10206 (SCI, IF=6.739)

[9]. Xiaofang Zhang, Wenxin Tang, Zhe Yang, Xingen Luo, Huiyan Luo, Di Gao, Ya Chen, Qing Jiang, Jie Liu* (共同通讯作者) and Zhaozhong Jiang*. PEGylated poly(amine-co-ester) micelles as biodegradable non-viral gene vectors with enhanced stability, reduced toxicity and higher in vivo transfection efficacy. Journal of Materials Chemistry B, 2014, 2: 4034–4044 (SCI)

[10]. Xiaofang Zhang, Bo Liu, Zhe Yang, Chao Zhang, Hao Li, Xingen Luo, Huiyan Luo, Di Gao, Qing Jiang, Jie Liu* (共同通讯作者), Zhaozhong Jiang*. Micelles of Enzymatically Synthesized PEG-Poly(amine-co-ester) Block Copolymers as pH-Responsive Nanocarriers for Docetaxel Delivery. Colloids and Surfaces B: Biointerfaces, 2014, 115: 349–358 (SCI, IF=4.287)

[11]. Zhe Yang, Xiaofang Zhang, Xingen Luo, Qing Jiang, Jie Liu * (共同通讯作者) and Zhaozhong Jiang*. Enzymatic Synthesis of Poly(butylene-co- sebacate-co-glycolate) Copolyesters and Evaluation of the Copolymer Nanoparticles as Biodegradable Carriers for Doxorubicin Delivery. Macromolecules, 2013, 46:1743–1753 (SCI, IF=5.927)

[12]. Zhe Yang, Xingen Luo, Xiaofang Zhang, Jie Liu (通讯作者) and Qing Jiang. Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid–polymer hybrid nanoparticles. Biomedical Materials, 2013, 8: 025012 (SCI, IF=2.922)

[13]. Jie Liu, Zhaozhong Jiang, Shengmin Zhang, Chen Liu, Richard A. Gross, Themis R. Kyriakides, W. Mark Saltzman. Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters. Biomaterials 2011, 32(27): 6646-6654 (SCI, IF=7.882)

[14]. Jie. Liu, Z.Z. Jiang, S.M. Zhang, et al. Enzyme-synthesized Poly(amine-co-esters) as Non-viral Vectors for Gene Delivery. Journal of Biomedical Materials Research: Part A 2010, 96A:456-465 (SCI, IF=3.044)

[15]. Jie. Liu, Z.Y. Qiu, S.M. Zhang, et al. A modified double-emulsion method for the preparation of daunorubicin-loaded polymeric nanoparticle with enhanced in vitro anti-tumor activity. Biomedical Materials 2010, 5(6) (SCI, IF=2.467)

[16]. Jie. Liu, Z.Z. Jiang, S.M. Zhang, et al. Poly(ω-pentadecalactone-co-butylene-co- succinate) nanoparticles as biodegradable carriers for camptothecin delivery. Biomaterials 2009, 30(29): 5707-5719 (SCI, IF=7.882)

荣誉获奖情况

广州市珠江科技新星（2012）

广东省科技创新青年拔尖人才（2014）

中山大学优秀青年教师培养计划（2014）


主要兼职

中国超声医学工程学会超声分子影像学专委会青年委员

中国生物材料学会会员

广东省生物医学工程学会会员