林旭东
林旭东博士，中山大学生物医学工程学院教授/博导，广东省杰青，逸仙学者，中山大学“百人计划”引进人才。2012年本科毕业于中山大学微电子学系，2017年博士毕业香港城市大学。2019年3月加入中山大学，从事生物医学传感方向的教学及科研工作。长期致力于微纳生物医学器件及系统的研究与开发，已以第一/通讯作者在Nature Communications, Advanced Materials, Advanced Functional Materials, Advanced Science, Small, Nano Letters，Biomaterials等高水平期刊发表研究工作多篇；授权国际发明专利及中国发明专利多项，并已成功转化5项中国发明专利（转化金额300万）；相关研究成果多次被中国日报等国内外知名新闻媒体报道。
一、主要经历
2025.03-至今： 中山大学，生物医学工程，教授
2019.03-2025.03：中山大学，生物医学工程，副教授
2017.05-2019.02：香港城市大学，生物医学工程系，博士后
2013.03-2017.04：香港城市大学，生物医学工程系，博士
2008.09-2012.07：中山大学，微电子学，学士
二、学科方向
以疾病（特别是神经系统疾病）诊断及治疗需求为导向，致力于微纳生物医学器件及系统的研发，探索其在大健康领域的应用新范式：
生物医药在体筛选：基于微流控技术和超快光学成像技术，设计开发针对小型模式生物（斑马鱼/线虫）的高通量筛选技术和平台，结合人工智能算法进行靶向药物的精准筛选；
远程精准神经调控：发展新型植入式微纳器件及系统，实现活体动物的远程、高时空分辨率的神经调控，用于脑科学基础研究以及脑疾治疗；
智能生物医学传感：开发基于微纳结构的生物医学传感技术，实现对复杂神经递质释放的快速，高灵敏度和高特异性的监测及相关脑部疾病诊断。
三、科研项目（主持）
1. 中国自然科学基金面上项目，2024-2027。
2. 中国自然科学基金青年科学基金项目，2020-2022。
3. 中央军委后勤保障部项目子课题，2021-2023。
4. 广东省自然科学基金杰出青年项目，2025-2027。
5. 广东省自然科学基金面上项目，2021-2023。
6. 深圳市基础研究面上项目， 2025-2027。
7. 深圳市稳定支持计划面上项目， 2022-2025。
8. 企业横向合作技术开发项目，2021-2024。
9. 中山大学百人计划启动基金项目，2019-2022。
10.中央高校基本科研业务费-青年教师培育项目， 2023-2024。
四、论著发明
代表性论文：
1. Xudong Lin, Xin Duan, Claire Jacobs, Jeremy Ullmann, Chung-Yuen Chan, Siya Chen, Shuk-Han Cheng, Wen-Ning Zhao, Annapurna Poduri, Xin Wang*, Stephen J. Haggarty* & Peng Shi*. “High-throughput brain activity mapping and machine learning as foundation for systems neuropharmacology”, Nature Communications, 9(1), 5142, (2018). (IF: 17.69)
2. Yuxin Liu, Xi Chen, Ye Liang, Hao Song, Peng Yu, Shunmin Guan, Zijian Liu, Anqi Yang, Minghui Tang, Yajing Zhou, Ying Zheng, Zhilun Yang, Lelun Jiang, Jufang He, Ning Tan, Bingzhe Xu, and Xudong Lin*；“Ferromagnetic Flexible Electronics for Brain-Wide Selective Neural Recording”, Advanced Materials, 35(6), 2208251, (2023). (IF: 32.08)
3. Hao Song, Yuxin Liu, Jing Li, Zijian Liu, Anqi Yang, Baicheng Lu, Yajing Zhou, Junhan Duan, Jialong Li, Jufang He, Xi Chen*, Xudong Lin*；“Ferromagnetic Fiber Systems for Multiplexing Neural Recording and Modulation with Spatial Selectivity”, Advanced Functional Materials, 34 (45), 2407537, (2024). (IF: 18.50)
4. Zijian Liu, Hao Song, Guanming Lin, Weicong Zhong, Yang Zhang, Anqi Yang, Yuxin Liu, Junhan Duan, Yajing Zhou, Kangjian Jiao, Donghai Ding, Yanwen Feng, Jun Yue, Wenjing Zhao, Xudong Lin*；“Wireless Intelligent Patch for Closed-loop In Situ Wound Management”, Advanced Science, 11 (29), 2400451, (2024). (IF: 15.1)
5. Minghui Tang,Xin Duan, Anqi Yang, Shijie He, Yajing Zhou, Yuxin Liu, Lu Zhang, Xuan Luo, Peng Shi*, Honglin Li*, Xudong Lin*；“Fish capsules: a system for high-throughput screening of combinatorial drugs”, Advanced Science, 9, 2104449, (2022). (IF: 17.52)
6. Xudong Lin, Tianying Sun, Minghui Tang, Anqi Yang, Richard Yan-Do, Da Chen, Yaobin Gao, Xin Duan, Ji-Jung Kai, Feng Wang, Peng Shi*. “3D Upconversion Barcodes for Combinatory Wireless Neuromodulation in Behaving Animals”, Advanced Healthcare Materials, 202200304, (2022). (IF: 11.09)
7. Minghui Tang, Xiaoge Zhang, Anqi Yang, Yuxin Liu, Kai Xie, Yajing Zhou, Chong Wang, Jie Liu*, Peng Shi*, Xudong Lin*；“Injectable Black Phosphorus Nanosheets for Wireless Non-genetic Neural Stimulation”, Small, 2105388, (2021). (IF: 15.15)
8. Anqi Yang, Xiang Lin, Zijian Liu, Xin Duan, Yurou Yuan, Jiaxuan Zhang, Qilin Liang, Xianglin Ji, Nannan Sun, Huajun Yu, Weiwei He, Lili Zhu, Bingzhe Xu*, Xudong Lin*；“Worm Generator: A System for High-Throughput in Vivo Screening”, Nano Letters, 23 (4), 1280–1288, (2023). (IF: 12.26)
9. Xudong Lin, Xian Chen, Wenchong Zhang, Qinghai Liao, Peilin Fang, Xi Chen, Jufang He, Ming Liu, Feng Wang*, Peng Shi*. “Core–Shell–Shell Upconversion Nanoparticles with Enhanced Emission for Wireless Optogenetic Inhibition”, Nano Letters, 18 (2), 948–956 (2018). (IF: 12.26)
10.Ying Wang, Xudong Lin, Xi Chen, Xian Chen, Zhen Xu, Wenchong Zhang, Qinghai Liao, Xin Duan, Xin Wang, Ming Liu, Feng Wang, Jufang He, Peng Shi*. “Tetherless Near-infrared Control of Brain Activity in Behaving Animals Using Fully Implantable Upconversion Microdevices”, Biomaterials, 142, 136-148 (2017, Co-first). (IF: 15.30)
11. Xudong Lin, Ying Wang, Xian Chen, Runhuai Yang, Zixun Wang, Jingyu Feng, Haitao Wang, King W. C. Lai, Jufang He, Feng Wang*, Peng Shi*. “Multiplexed Optogenetic Stimulation of Neurons with Spectrum-Selective Upconversion Nanoparticles”, Advanced Healthcare Materials, 6(17): 1700446 (2017). (IF: 11.09)
其他论文：
1. Junhan Duan, Guanming Lin, Kangjian Jiao, Xiaohui Hong, Xudong Lin*, “Fully automated in vivo screening system for multi-organ imaging and pharmaceutical evaluation”. Microsystems & Nanoengineering, 11 (1), 22, 2025. (IF=7.3)
2. Lijuan He, Hongxia Du, Yi Yang, Zhihua Guan, Jinjin Li, Honglin Li, Xudong Lin*, Lili Zhu*, “A lateral-immobilization zebrafish microfluidic chip-based system for in vivo real-time evaluation of antithrombotic agents”. Chinese Chemical Letters, 35 (3), 109013, 2024. (IF=9.4)
3. Weiwei He, Hongbo Zhang, Xudong Lin, Lili Zhu, Tingting Zheng, Hao Pei, Yang Tian, Min Zhang, Guoyue Shi, Lei Wu, Jianlong Zhao, Gulinuer Wumaier, Shengqing Li, Yufang Xu*, Honglin Li*, Xuhong Qian*, “Advancements in life-on-a-chip: The impact of “Beyond Limits Manufacturing” technology”. Chinese Chemical Letters, 35 (5), 109091, 2024. (IF=9.4)
4. Yuanyuan Li, Zhipeng Chen, Yuxin Liu, Zijian Liu, Tong Wu, Yuanxi Zhang, Lelun Peng, Xinshuo Huang, Shuang Huang, Xudong Lin, Xi Xie*, Lelun Jiang*. “Ultra-low frequency magnetic energy focusing for highly effective wireless powering of deep-tissue implantable electronic devices”, National Science Review, 11(5), nwae062, (2024). (IF: 16.3)
5. Yan Liu, Yang Wang, Jiayi Zhu, Xuxian Su, Xudong Lin, Liang Xu*, Xiwen Xing*, “Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells”. Chinese Chemical Letters, 35 (9), 109427, 2024. (IF=9.4)
6. Xiaoping Hu, Jingdun Xie, Yilin Yang, Ziyi Qiu, Weicheng Lu, Xudong Lin*, Bingzhe Xu*；“Multi-Target Neural Differentiation (MTND) Therapeutic Cocktail to Suppress Brain Tumor”, International Journal of Molecular Sciences, 24 (15), 12329, (2023). (IF: 4.9)
7. Yilin Yang, Xiaoping Hu, Yuxin Liu, Bin Ouyang, Jiaxi Zhang, Huawei Jin, Zhenhua Yu, Ruiwei Liu, Zhe Li, Lelun Jiang, Xudong Lin, Bingzhe Xu*, “An implantable ultrasound-powered device for the treatment of brain cancer by using electromagnetic fields”. Science Advances, 2022. (IF=14.95)
8. Xin Duan, Wei Wang, Minghui Tang, Feng Gao, Xudong Lin*；“Dissecting cellular heterogeneity based on network denoising of scRNA-seq using local scaling self-diffusion”, Frontiers in Genetics, 12, 811043, (2022). (IF: 4.77)
9. Kai Xie, Naixiang Wang, Xudong Lin, Zixun Wang, Xi Zhao, Peiling Fang, Haibing Yue, Junhwi Kim, Jing Luo, Shaoyang Cui, Feng Yan*, Peng Shi*. “Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo”, Elife, e50345, (2020). (IF: 8.71)
10. Chong Wang, Haibing Yue, Wei Huang, Xudong Lin, Xiaoqiong Xie, Zhi He, Xiao He, Sanbiao Liu, Lu Bai Bingheng Lu, Yen Wei, Min Wang*. “Cryogenic 3D printing of heterogeneous scaffolds with gradient mechanical strengths and spatial delivery of osteogenic peptide/TGF-β1 for osteochondral tissue regeneration”, Biofabrication, 12(2), (2020, co-first). (IF: 11.06)
11. Lu, Haojian, Yuanyuan Yang, Xudong Lin, Peng Shi, and Yajing Shen. "Low-Invasive Cell Injection based on Rotational Microrobot." Advanced Biosystems, 1800274 (2019).
12. Xudong Lin, Vincent W. T. Li, Siya Chen, Chung-Yuen Chan, Shuk-Han Cheng, and P. Shi*. “Autonomous system for cross-organ investigation of ethanol-induced acute response in behaving larval zebrafish”, Biomicrofluidics, 10, 024123 (2016). (IF: 3.25)
13. Xudong Lin, Shiqi Wang, Xudong Yu, Zhuguo Liu, Fei Wang, Wai Tsun Li, Shuk Han Cheng, Qiuyun Dai, and Peng Shi*. “High-throughput Mapping of Brain-wide Activity in Awake and Drug-responsive Vertebrates”, Lab on a Chip, 15(3):680-9 (2015). (IF: 7.51)
14. Xu Bingzhe, Lin Xudong, Li Wei, Wang Zixun, Zhang Wenchong, Shi Peng*. “Cell Generator: A Self-sustaining Bio-hybrid System Based on Energy Harvesting from Engineered Cardiac Micro-tissues”, Advanced Functional Materials, 1606169 (2017). (IF: 19.92)
15. Ma Lili, Lin Xudong, Li Cai, Xu Zoufeng, Chan Chun-Yin, Tse Man-Kit, Shi Peng, Zhu Guangyu*. “A Cancer Cell-Selective and Low-Toxic Bifunctional Heterodinuclear Pt (IV)-Ru (II) Anticancer Prodrug”, Inorganic chemistry, 57(5), 2917-2924 (2018). (IF: 5.43)
16. Wei Li, Zhen Xu, Bingzhe Xu, Chung Yuen Chan, Xudong Lin, Ying Wang, Ganchao Chen, Zhigang Wang, Qiuju Yuan, Guangyu Zhu, Hongyan Sun, Wutian Wu, and Peng Shi*. “Investigation of the Subcellular Neurotoxicity of Amyloid-β Using a Device Integrating Microfluidic Perfusion and Chemotactic Guidance”, Advanced Healthcare Materials, 1600896 (2017). (IF: 11.09)
17. Yu Gao, Chon U Chan, Qiushi Gu, Xudong Lin, Wencong Zhang, Chen Loong Yeo, Astrid Marlies Alsema, Manish Arora, Seow Khoon Chong, Peng Shi, Claus-Dieter Ohl and Chenjie Xu. “Controlled nanoparticle release from stable magnetic microbubble oscillations”, NPG Asia Materials, 8, e260 (2016). (IF: 10.76)
18. Wei Li, Rongcong Luo, Amol D. jadhav, Zicong Zhang, Xudong Lin, Li Yan, Xianfeng Chen, Jufang He, Chia-Hung Chen, P. Shi*, “Remote Modulation of Neural Activities via Near-infrared Triggered Release of Biomolecules”, Biomaterials, 65: 76-85 (2015). (IF: 15.30)
19. Jinfeng Zhang, Yu-Chuan Liang, Xudong Lin, Xiaoyue Zhu, Li Yan, Shengliang Li, Xia Yang, Guangyu Zhu, Andrey L. Rogach, Peter K. N. Yu, Peng Shi, Lung-Chen Tu, Chia-Ching Chang, Xiaohong Zhang, Xianfeng Chen, O Wenjun Zhang, and Chun-Sing Lee*. “Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo”, ACS Nano, 9(10), 9741-9756 (2015). (IF: 18.02)
20. Qiang Ju, Xian Chen, Fujin Ai, Dengfeng Peng, Xudong Lin, Wei Kong, Peng Shi, Guangyu Zhu and Feng Wang. “An upconversion nanoprobe operating in the first biological window”, J. Mater. Chem. B, 3, 3548-3555 (2015). (IF: 6.3)
21. Wei Li, Zhen Xu, Xudong. Lin, Rongcong Luo, Chia-Hung Chen, Peng Shi*, “NeuroArray: A Universal Interface for Patterning and Interrogating Neural Circuitry with Single Cell Resolution”, Scientific Reports, 4:4784 (2014). (IF: 4.4)
授权专利：
中国发明专利：
1.林旭东、唐明卉；一种无泵固定斑马鱼微流体芯片系统及其制备方法与用；2021，中国，授权号：ZL202011020472.5。
2.林旭东、唐明卉；一种多样品斑马鱼幼苗高通量微流控芯片、筛选系统及其应用；2021，中国，授权号：ZL202011203977.5。
3.林旭东、唐明卉；一种用于斑马鱼幼鱼的微流控芯片、系统及其应用；2020，中国，授权号：ZL202010546028.0。
4.林旭东、周雅静、唐明卉、刘笑笑，一种模式动物无麻醉定向包埋方法及其系统；2023，中国，授权号：ZL202111578617.8。
美国发明专利：
1. US Patent, No. 9,897,593, 2018; Systems and Methods for Automated Handling of Live Organisms.
2. US Patent, No. 11,103,725, 2021; Wireless Optogenetic Device and Associated Radiation System.
3. US Patent, No. 16/127,471, 2022; Method and a system for analyzing neuropharmacology of a drug.
五、招聘/招生
课题组欢迎同行学术交流及校企合作，亦诚邀副教授，助理教授，博后等各式志同道合的人才加入，有意者请随时与林旭东博士联系。同时，欢迎生物医学工程、机械工程、电子工程、信息工程、材料工程，医学等专业背景的本科/研究生加入。课题组本科生已在国家级、省级、校级等各项学科竞赛中取得多项优异成绩（如全国生医工竞赛一等奖，挑战杯金奖等），期待渴望参与课外科学研究的本科生加入课题组学习。
六、主讲课程
《生物医学传感器》、《生物医学传感器实验》
七、联系方式
1、地址：广东省深圳市中山大学深圳校区医学园2-508
2、邮箱：linxd37@mail.sysu.edu.cn；
