易长青
个人简介
易长青，教授/博导，厦门大学学士（2001）、硕士（2004），香港城市大学博士（2008）；现任中山大学生物医学工程学院院长助理，广东省便携式普及型先进实用医疗器械工程技术研究中心副主任，科技部重点研发计划战略性科技创新合作重点专项项目负责人，曾获广东省特支计划“科技创新青年拔尖人才”和广州市“珠江科技新星”计划资助。
一直从事生化传感检测领域的基础和应用研究，致力于开发用于现场即时检测的生物医学传感新技术、柔性可穿戴传感新器件和便携式智能化新仪器，实现复杂样本中生化标志物的高灵敏和高特异性检测。作为项目负责人已主持完成了国家和省市级、以及企业委托项目15项，发表高水平研究论文100余篇（ESI高被引5篇），h-index 因子37.0；获授权中国发明专利12项、实用新型专利16项、外观设计专利2项、软件著作权4项，并有16项发明专利和1项PCT专利已公开。
Email：yichq@mail.sysu.edu.cn
课题组网站：http://bme.sysu.edu.cn/bmenano/
研究方向
1.生物医学传感技术：基于纳米材料的可控合成与功能化，开发生物医学传感新技术和多元分析新探针，实现复杂样本中和细胞内生化标志物的超灵敏和高特异性检测与成像；
2.现场快速检测系统：基于智能移动终端和单片机平台，开发高灵敏和高特异的生物医学传感新器件和便携式智能化新仪器，实现复杂样本中生化标志物的原位现场快速检测；
3.纳米生物材料：从分子到细胞水平研究纳米材料与生物大分子相互作用机理，基于纳米材料的可控合成与功能化，开发诊疗一体化纳米生物新材料用于生物成像和同步治疗。
荣誉获奖情况
1.广东省高等学校“千百十工程”校级培养对象(2012)
2.广州市珠江科技新星(2013)
3.“广东特支计划”科技创新青年拔尖人才(2014)
4.广东省科学技术奖三等奖（2018）
5.第二届“源创杯”创新创意大赛优胜奖（2019）
6.中山大学第十届教学成果奖（2021）
7.深圳市科技进步奖二等奖（2021）
主持的科研项目
1.国家重点研发计划战略性科技创新合作重点专项，“用于多种呼吸道病原体同步即时检测(POCT)的技术与便携式装置开发”，2022.09-2024.08，项目负责人（PI）
2.广州市科学技术局农业和社会发展重点专项，“可卡因、苯丙胺和芬太尼类药物现场快检技术与可穿戴设备”，2023.04-2026.03，项目负责人（PI）
3.深圳市科技创新委员会国际合作项目，“冷链食品中典型病原菌现场快速筛查（POCT）技术与智能化系统研发”，2022.07-2024.06，项目负责人（PI）
4.广东省自然科学基金凯普生物联合基金，“多种病原体核酸标志物现场快速可视化检测方法”，2021.11-2024.10，项目负责人（PI）
5.深圳市科技创新委员会基础研究项目，“多种农药残留同步即时检测技术与便携式装置研究”，2021.11-2024.10，项目负责人（PI）
6.公安部重点实验室开放课题，“滥用药物的现场快检技术研发”， 2022. 12-2024.11，项目负责人（PI）
7.高校基本科研业务费，“超灵敏实时探测XX的传感技术与可穿戴设备研究”，2019.01-2020. 12，项目负责人(PI)
8.广东省自然科学基金面上项目，“纳米多元检测体系的构建及其在肺癌早期诊断中的应用”，2017.05-2020.05，项目负责人(PI)
9.深圳市科技创新委员会基础研究项目，“同步检测多种肿瘤标志物的纳米生物传感技术及其在肺癌早期诊断中的应用”，2017.06-2019.05，项目负责人（PI）
10.高校基本科研业务费-重大项目和前沿新兴交叉学科培育资助计划，“基于荧光碳点的多种肿瘤标志物同步检测新方法和配套仪器的研发”，2017.05-2018. 12，项目负责人(PI)
11.广东省科技厅科技发展专项-前沿与关键技术创新项目，“用于食品中多种危害因子同步检测的微纳传感技术与器件的研发”，2016.07-2018.06，项目负责人(PI)
12.广东省委组织部广东省科技创新青年拔尖人才，“生物诊断”，2015.04-2018.03，项目负责人(PI)
13.广州市科学技术局珠江科技新星专项，“纸质微流控芯片系统的研制及其在食品安全检测中的应用”，2013.01-2015.12，项目负责人(PI)
14.国家自然科学基金，“多功能纳米材料的合成及其用于细胞成像与同步治疗的研究”，2012.01-2014.12，项目负责人(PI)
15.广东省自然科学，“用于实时监测细胞凋亡的纳米生物传感器的研究”，2011. 10-2013.10，项目负责人(PI)
16.横向项目，“乳品中有害因子超灵敏组合荧光纳米-微流控平台的应用研究” ，2014.09-2015.08，项目负责人(PI)
17.横向项目，“微流控细胞阵列芯片用于重要赤潮毒素检测的研究”，2012.09-2013.05，项目负责人(PI)
18.深圳市科技创新委员会基础研究项目，“用于癌症诊断和同步治疗的纳米药物研究”，2012.05-2014.5，项目负责人（PI）
19.中山大学“百人计划”项目，2011.06-2012.12，项目负责人(PI)
参与的科研项目
1.广州市科学技术局农业和社会发展重点专项，“基于“脾主涎”探索唾液淀粉酶现场即时检测系统在糖脂代谢性疾病的应用”，2023. 04-2026.03
2.深圳市科技创新委员会深港澳科技计划C类项目，“用于新冠病毒和流感病毒现场筛查的快速检测技术和便携式微纳机电系统”，2021.07-2023.06
3.横向项目，可穿戴式连续血糖监测仪（CGM），2020.11-2021.05
4.广州市科学技术局农业和社会发展重点专项，“基于智能手机的真菌毒素快速检测技术及装置研究”，2018.04-2021.03
5.广东省科技厅省部产学研项目，“新型甲型肝炎病毒诊断核心试剂的研发及产业化”，2012.01-2013.12
6.广州市科学技术局基础研究项目，“基于微流控与纳米生物传感技术的便携式仪器的开发”，2014.01-2015.12
7.深圳市科技创新委员会基础研究计划，“面向乳品“全检测”新型荧光纳米探针-微流控平台的基础研究”，2013.07-2016.01
8.深圳市科技创新委员会深港创新圈计划，“微流控细胞阵列芯片用于重要赤潮毒素检测的研究”，2010.10-2012.09，
论文：
1.Chen, X.; Dai, D. S.; Ma, J. P.; Yu, Z. P.; Zhao, J. K.; Yi, C. Q*. “A MMP-2 responsive nanotheranostic probe enabled synergistic therapy of rheumatoid arthritis and MR/CT assessment of therapeutic response in situ”. 2023, Adv. Healthc. Mater., 2300962.
2.Xu, N. X.; Xiao, M.; Yu, Z. P.; Jin, B. H.; Yang, M. S.; Yi, C. Q*. “On-site quantitation of xanthine in fish and serum using a smartphone-based spectrophotometers integrated with a dual-readout nanosensing assay”. 2023, Food Chem. 431, 137107.
3.Xiao, M.; Xu, N. X.; He, A. T.; Yu, Z. P.; Chen, B.; Jin, B. H.*; Jiang, L. L.*; Yi, C. Q*. “Development of the smartphone-based fluorospectrophotometer and ratiometric fluorescence nanoprobe for on-site quantitation of pesticide residue”. 2023, iScience. 26, 106553.
4.Yang, J.; Gong, X.; Chen, S. J.; Zheng, Y.; Peng, L. L.; Liu, B.; Chen, Z. P.; Xie, X.; Yi, C. Q*; Jiang, L. L.* “Development of smartphone-controlled and microneedle-based wearable continuous glucose monitoring system for home-care diabetes management”. 2023, ACS Sen. 8, 1241-1251.
5.C. Cai, F. Tian, J. Ma, Z. Yu, M. Yang, Yi, C. Q*. “BSA-templated synthesis of Ir/Gd bimetallic oxide nanotheranostics for MR/CT imaging-guided photothermal and photo- dynamic synergistic therapy”. 2023, Nanoscale 15, 4457-4468.
6.Xia, S. Q.; Pan, J. F.; Dai, D. S.; Dai, Z*.; Yang, M. S*.; Yi, C. Q*. “Design of portable electrochemiluminescence sensing systems for point-of-caretesting applications”. 2023, Chin. Chem. Lett., 34, 107799.
7.Zhou, Q. Q.; Pan, J. F.; Mo, L. M.; Luo, Z. F.; Qin, Z. F.; Dai, Z.; Yi, C. Q*. “Fluorescent on-site detection of multiple pathogens using smartphone-based portable device with paper-based isothermal amplification chip” 2022, Microchim. Acta, 189, 333.
8.Xiao, M.; Tian, F.; Liu, X.; Zhou, Q. Q.; Pan, J. F.; Luo, Z. F*.; Yang, M*.; Yi, C. Q*. “Virus detection: From state-of-the-art laboratories to smartphone-based point-of-care testing” 2022, Adv. Sci., 9, 2105904.
9.Liu, Y.; Xiao, M.; Xu, N. X.; Yang, M. S.; Yi, C. Q*. “Point-of-need quantitation of 2,4-dichlorophenoxyacetic acid using a ratiometric fluorescent nanoprobe and a smartphone-based sensing system” 2022, Sensor Actuat B-Chem., 367, 132083.
10.Hou, M. F.; Chen, W. D.; Zhao, J. K.; Dai, D. S.; Yang, M.; Yi, C. Q*. “Facile synthesis and in vivo bioimaging applications of fluorescent polymer nanoparticles” 2022, Chin. Chem. Lett., 33, 4101-4106.
11.Yang, J.; Yang, J. B.; Gong, X.; Zheng Y.; Yi, S. Z.; Cheng, Y. X.; Li, Y. J.; Liu, B.; Xie, X.; Yi, C. Q*.; Jiang, L. L.* “Recent progress in microneedles-mediated diagnosis, therapy, and theranostic systems” 2022, Adv. Healthc. Mater., 367, 2102547.
12.Yang, J.; Cheng, Y. X.; Gong, X.; Yi, S. Z.; Li, C.-W.; Jiang, L. L*.; Yi C. Q*. “An integrative review on the applications of 3D printing in the field of in vitro diagnostics” 2022, Chin. Chem. Lett., 33, 2231-2242.
13.Cheng, Y. X.; Gong, X.; Yang, J.; Zheng, G. Z.; Zheng Y.; Li, Y. J.; Xu, Y. S.; Nie, G.; Xie, X.; Chen, M. W.; Yi, C. Q*.; Jiang, L. L.* “A touch-actuated glucose sensor fully integrated with microneedle array and reverse iontophoresis for diabetes monitoring” 2022, Biosens. Bioelectron., 203, 114026
14.Yang, J.; Zhang, Y. L.; Zhao, J. K.; Ma, J. P.; Yi, C. Q*. “Development of gold nanoparticles-aptamer nanocomposite for multiplexed analysis of antibiotics and design of molecular logic gates”. 2022, Nanotechnology 33, 015501
15.Yin, B. H.; Zhang, Q.; Xia, X. Y.; Li, C. Q.; Ho, W. K. H.; Yan, J. X.; Huang, Y. Y.; Wu, H. L.; Wang, P. ; Yi, C. Q.; Hao, J. H.; Wang, J. F.; Chen, H. L.; Wong, S. H. D.; Yang, M*. “A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection”. 2022, Theranostics, 12, 5914-5930.
16.Wang, J. H.; Gu, Y. T.; Liu, X.; Fan, Y. D.; Zhang, Y.; Yi, C. Q.; Cheng, C. M.; Yang, M*. Near-Infrared Photothermally-Enhanced Photooxygenation for Inhibition of Alzheimer’s Amyloid-β Aggregation and Attenuation of Neurotoxicity Based on Brain-Targeting Peptide RVG conjugated Two-dimensional Porphyrinic Metal-Organic Framework@Indocyanine Gre, 2022 Int. J. Mol. Sci., 23, 10885
17.Tian, F.; Zhong, X. J.; Zhao, J. K.; Gu, Y. T.; Fan, Y. D.; Shi, F.; Zhang, Y.; Tan, Y. H.; Chen, W.; Yi, C. Q*.; Yang, M*. “Hybrid theranostic microbubbles for ultrasound/ photoacoustic imaging guided starvation/low-temperature photothermal/hypoxia-activated synergistic cancer therapy” 2021, J. Mater. Chem. B, 9, 9358-9369.
18.Shi, Y. P.; Liu, J. J.; Zhang, Y.; Bao, J. F.; Cheng, J. L*.; Yi C. Q*. “Microwave-assisted synthesis of colorimetric and fluorometric dual-functional hybrid carbon nanodots for Fe3+ detection and bioimaging” 2021, Chin. Chem. Lett., 32, 3189-3194.
19.Chen, W. D.; Zhao, J. K.; Hou, M. F.; Yang, M.; Yi, C. Q*. “Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photo- dynamic therapy”. 2021, Nanoscale 13, 16197-16206
20.Xiao, M.; Zhou, Q. Q.; Zhang, H.; Zhou, L. F.; Ma, J. P.; Yi, C. Q*. “Logic gate design using multi-color fluorescent carbon nanodots for smartphone-based information extraction”. 2021, ACS Appl. Nano Mater. 4, 8184-8191.
21.Liu, Z. G.; Xiao, M.; Yang, R. Z.; Zhou, Q. Q.; Ye, H. F.; Yi C. Q*. “Multiplexed detection of Fe3+, cobalamin and folate using fluorescent nanoprobe-based microarrays and a smartphone”. 2021, Journal of Analysis and Testing 5, 19-29.
22.Wang, Q.; Shi, Y. P.; Chen, W. D.; Li, C.-W.; Yang, M.; Yi C. Q*. “Synthesis of fluorescent nanoprobe with simultaneous response to intracellular pH and Zn2+ for tumor cell distinguishment”. 2021, Microchim. Acta, 188, 9
23.Zhao, J. K.; Chen, X.; Ho, K.-H.; Cai, C.; Yang, M*.; Yi C. Q*. “Nanotechnology for diagnosis and therapy of rheumatoid arthritis: Evolution towards theranostic approaches”. 2021, Chin. Chem. Lett., 32, 66-86.
24.Oudeng, G.; Benz, M.; Popova, A. A.; Zhang, Y.; Yi, C. Q.; Levkin, P. A. * and Yang, M*. “Droplet Microarray Based on Nanosensing Probe Patterns for Simultaneous Detection of Multiple HIV Retroviral Nucleic Acids”. 2020, ACS Appl. Mater. Interfaces, 12, 55614- 55623.
25.Zhang, Y. L.; Li, C.-W.; Zhou, L. F.; Chen. Z. P.; Yi, C. Q*. ““Plug and Play” logic gate construction based on chemically triggered fluorescence switching of gold nanoparticles conjugated with Cy3-tagged aptamer”. 2020, Microchim. Acta, 187, 437
26.Fang, Y. N.; Zhou, L. F.; Zhao, J. K.; Zhang, Y. L.; Yang, M.; Yi, C. Q*. “Facile synthesis of pH-responsive gadolinium(III)-doped carbon nanodots with red fluorescence and magnetic resonance properties for dual-readout logic gate operations”. 2020, Carbon, 166, 265-272. (Impact Factor = 11.307)
27.Fang, Y. N.; Zhou, L. F.; Yang, J.; Zhao, J. K.; Zhang, Y. L.; Yi, C. Q*. “Multi-level, dual-readout logic operations based on pH-responsive holmium(III)-doped carbon nanodots”. 2020, ACS Appl. Bio Mater., 3, 3761-3769.
28.Xu, Z. Z.; Liu, Z. J.; Xiao, M.; Jiang, L. L*.; Yi, C. Q*. “A smartphone-based quantitative point-of-care testing (POCT) system for simultaneous detection of multiple heavy metal ions”. 2020, Chem. Eng. J. 394, 124966.
29.Xiao, M.; Liu, Z. G.; Xu, N. X.; Jiang, L. L.; Yang, M. S.; Yi, C. Q*. “A smartphone-based sensing system for on-site quantitation of multiple heavy metal ions using fluorescent carbon nanodots-based microarrays”. 2020, ACS Sen. 5, 870-878.
30.Ma, J. P.; Li, C.-W*.; Yi, C. Q*. “Facile synthesis and functionalization of color-tunable Ln3+-doped KGdF4 nanoparticles on a microfluidic platform” 2020, Mater. Sci. Eng. C-Mater. Biol. Appl. 108,110381.
31.Cheng, M.; Zhou, L. F.; Ma, J. P.; Mu, J. J.; Yi, C. Q*., Li, M. J*. “Iridium(III) and gadolinium(III) loaded and peptide-modified silica nanoparticles for photoluminescence and magnetic resonance (dual) imaging”. 2019, Mater. Sci. Eng. C-Mater. Biol. Appl. 104, 109972.
32.Guan, T.; Huang, W. Z.; Xu, N. X.; Xu, Z. Z.; Jiang, L. L.; Li, M. T.; Wei, X. Q.; Liu, Y. J.; Shen, X.; Li, X. M.; Yi, C. Q*., Lei, H. T.* “Point-of-need detection of microcystin-LR using a smartphone-controlled electrochemical analyzer”. 2019, Sensor Actuat B-Chem., 294, 132-140.
33.Gao, J.; Huang, W. Z.; Chen, Z. P.; Yi, C. Q*. Jiang, L. L.* “Simultaneous detection of glucose, uric acid and cholesterol using flexible microneedle electrode array-based biosensor and multi-channel portable electrochemical analyzer”. 2019, Sensor Actuat B-Chem., 287, 102-110.
34.Chen, W. D.; Wang, Q.; Ma, J. P.; Li, C.-W.; Yang, M. Yi C. Q*. “A ratiometric fluorescent core-shell nanoprobe for sensing and imaging of zinc(II) in living cell and zebrafish”. 2018, Microchim. Acta, 185,523
35.Wang, J. H.; Fan, Y. D.; Lee, H. W.; Yi C. Q.; Cheng, C. M.* Zhao, X.; Yang, M.* “Ultrasmall metal-organic framework Zn-MOF-74 nanodots: size-controlled synthesis and application for highly selective colorimetric sensing of iron(III) in aqueous solution”. 2018, ACS Appl. Nano Mater. 1, 3747–3753.
36.Alam, M. K.; Koomson, E.; Zou, H.; Yi C. Q.; Li, C.-W.; Xu, T.; Yang, M. S*. “Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007- 2017)”. 2018, Anal. Chim. Acta 1044, 29–65
37.Fang, Y. N.; Jia, J.; Yang, J.; Zheng, J. H.*; Yi C. Q*. “Facile preparation of holmium(III)-doped carbon nanodots for fluorescence/magneticresonance dual-modal bioimaging”. 2018, Chin. Chem. Lett., 29, 1277-1280.
38.Cao, X.-H.; Wang, Q.; Li J.; Yi C. Q.; Li, M. J*. “Gold nanoparticles functionalized with Ru(II)bipyridyl labeled DNA as a luminescent probe for the sensitive determination of DNase I”. 2017, Microchim. Acta, 184, 3273–3279. (Impact Factor = 6.408)
39.Li, C.-W*.; Zhu, Y.; Zhan, J. S.; Ma, J. P.; Gu, L. J.; Fang, Y. N.; Yi C. Q*. “Separation of polystyrene nanoparticles in polydimethylsiloxane microfluidic devices with a combined titania and sodium dodecyl sulfate inner coating”. 2017, Microchim. Acta, 184, 2227-2239. (Impact Factor = 6.408)
40.Liu, Z. G.; Zhang, Y. L.; Xu, S. J.; Zhang, H.; Tan, Y. X.; Ma, C. M.; Song, R.; Jiang, L. L.*; Yi C. Q*. “A 3D printed smartphone optosensing platform for point-of-need food safety inspection”. 2017, Anal. Chim. Acta 966, 81-89 (Impact Factor = 6.911)
41.Jiang, X. Q.; Tang, P. J.; Gao, P. P.; Zhang, Y. S.; Yi, C. Q*, Zhou, J. H.* “Gold nanoprobe- enabled three-dimensional ozone imaging by optical coherence tomography”. 2017, Anal. Chem. 89, 2561-2568 (Impact Factor = 8.008)
42.Pan, Y.; Yang, J.; Fang, Y. N.; Zheng, J. H.; Song, R.; Yi C. Q*. “One-pot synthesis of gadolinium-doped carbon quantum dots for high-performance multimodal bioimaging”. 2017, J. Mater. Chem. B 5, 92-101 (Impact Factor = 7.571)
43.Ma, J. P.; Lee, S. M.-Y.; Yi C. Q*.; Li, C.-W*. “Controllable synthesis of functional nanoparticles by microfluidic platform for biomedical applications - A review”. 2017, Lab Chip 17, 209-226 (Impact Factor = 7.517)
44.Pan, Y.; Shi, Y. P.; Chen, Z. H.; Chen, J. Y.; Hou, M. F.; Chen, Z. P.; Li, C.-W.; Yi C. Q*. “Design of multiple logic gates based on chemically triggered fluorescence switching of functionalized polyethyleneimine”. 2016, ACS Appl. Mater. Interfaces, 8, 9472-9482.
45.Pan, Y.; Shi, Y. P.; Chen, J. Y.; Wong, C-M.; Zhang, H.; Li, M. J*.; Li, C.-W*.; Yi C. Q*.“Grafting polyethylenimine with quinoline derivatives for targeted imaging of intracellular Zn2+ and logic gate operations”. 2016, Mater. Sci. Eng. C-Mater. Biol. Appl. 69, 561-568.
46.Zhang, Z. M.; Pan, Y.; Fang, Y. N.; Zhang, L. L.; Chen, J. Y.; Yi C. Q*. “Tuning photoluminescence and surface properties of carbon nanodots for chemical sensing”. 2016, Nanoscale 8, 500-507.
47.Zhang, Y. L.; Qi, S. J.; Liu, Z. G.; Yue, W. Q*.; Shi, Y. P.; Yi C. Q*. “Rapid determination of dopamine in human plasma using a gold nanoparticle-based dual-mode sensing system”. 2016, Mater. Sci. Eng. C-Mater. Biol. Appl. 61, 207-213.
48.Shi, Y. P.; Pan, Y.; Zhong, J.; Yang, J.; Zheng, J. H.; Cheng, J. L.; Song, R.; Yi C. Q*. “Facile synthesis of gadolinium (Ⅲ) chelates functionalized carbon quantum dots for fluorescence and magnetic resonance dual-modal bioimaging”. 2015, Carbon, 93, 742-750.
49.Zhang, H.; Zhang, Y. L.; Lin, Y. K.; Liang, T. W.; Chen, Z. H.; Li, J. F.; Yue, Z. F.; Lv J. Z.; Jiang, Q.; Yi C. Q*. “Ultrasensitive detection and rapid identification of multiple foodborne pathogens with the naked eyes”. 2015, Biosens. Bioelectron., 71, 186-193.
50.Wu, Z. Z.; Mu, J. J.; Wang, Q.; Chen, X.; Jensen, L.; Yi C. Q*.; Li, M. J*. “Hydroxyl and amino functionalized cyclometalated Ir(III) complexes: synthesis, characterization and cytotoxicity studies”. 2015, J. Organomet. Chem., 791, 175-182.
51.Jiang, J. Y.; Zhan, J. S.; Yue, W. Q.; Yang, M. S.; Yi C. Q*.; Li, C.-W*. “A single low-cost microfabrication approach for polymethylmethacrylate, polystyrene, polycarbonate and polysulfone based microdevices”. 2015, RSC Adv., 5, 36036-36043.
52.Shi, Q. N*.; Shi, Y. P.; Pan, Y.; Yue, Z. F.; Zhang, H.; Yi C. Q*. “Colorimetric and bare eye determination of urinary methylamphetamine based on the use of aptamers and the salt-induced aggregation of unmodified gold nanoparticles”. 2015, Microchim. Acta, 182, 505–511.
53.Yi C. Q.; Liu, L.; Li, C. W.; Zhang, J. C.; Yang, M. S*. “Synthesis, Characterization and Biomedical Application of Multifunctional Luminomagnetic Core-Shell Nanoparticles”. 2015, Mater. Sci. Eng. C-Mater. Biol. Appl. 46, 32-40.
54.Shi, Y. P.; Chen, Z. H.; Cheng, X.; Pan, Y.; Zhang, H.; Zhang, Z. M.; Li, C. W.; Yi C. Q*.; “A Novel Dual-Emission Ratiometric Fluorescent Nanoprobe for Sensing and Intracellular Imaging of Zn2+”. 2014, Biosens. Bioelectron., 61, 397-403.
55.Zhang, H.; Shi, Y. P.; Lan, F.; Pan, Y.; Lin, Y. K.; LV, J. Z.; Zhu, Z. H.; Jiang, Q.; Yi C. Q*. “Detection of single-digit foodborne pathogens with the naked eye using carbon nanotube-based multiple cycle signal amplification”. 2014, Chem Commun 50, 1848-1850.
56.Shi, Y. P.; Pan, Y.; Zhang, H.; Zhang, Z. M.; Li, M. J.; Yi C. Q*.; Yang M. S. “A dual-mode nanosensor based on carbon quantum dots and gold nanoparticles for discriminative detection of glutathione in human plasma”. 2014, Biosens. Bioelectron., 56, 39-45.
57.Zhang, Z. M.; Shi, Y. P.; Pan, Y.; Cheng, X.; Zhang, L. L.; Chen, J. Y.; Li, M. J.; Yi C. Q*. “Quinoline derivative-functionalized carbon dots as a fluorescent nanosensor for sensing and intracellular imaging of Zn2+”. 2014, J. Mater. Chem. B 2, 5020-5027
58.Zhang, H.; Lan, F.; Shi, Y. P.; Wan, Z. G.; Yue, Z. F.; Fan, F.; Lin, Y. K.; Tang, M. J.; LV, J. Z*.; Xiao, T*.; Yi C. Q*. “A “Three-in-One” Sample Preparation Method for Simultaneous Determination of B-group Water-soluble Vitamins in Infant Formula Using VitaFast® Kits”. 2014, Food Chem 153, 371-377.
59.Li, M. J*.; Lan, T. Y.; Cao, X. H.; Yang H. H., Shi, Y. P.; Yi C. Q*.; Chen G. N. “Synthesis, characterization, DNA binding, cleavage and cytotoxicity of copper(II) complexes”. 2014, Dalton Trans., 43, 2789-2798.
60.Liu, D. D.; Yi C. Q.; Wang, K. Q.; Fong, C. C.; Wang, Z. K.; Lo, P. K.; Sun, D.; Yang, M. S*. “Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in a silicon nanowire microenvironment”. 2014, Nanomedicine 10, 1153-1163.
61.Li, C.-W*.; Yu, G. D.; Jiang, J. Y.; Lee, S. M.-Y.; Yi, C. Q.; Yue, W. Q.; Yang, M. S. “A microfluidic linear node array for the study of protein-ligand interaction”. 2014, Lab Chip 14, 3993-3999
62.Shi, Y. P.; Yi C. Q*.; Zhang, Z. M.; Zhang, H.; Li, M. J.; Yang, M. S.; Jiang, Q. “Peptide-bridged Assembly of Hybrid Nanomaterial and Its Application for Caspase-3 Detection”. 2013, ACS Appl. Mater. Interfaces 5, 6494-6501.
63.Shi, Y. P.; Zhang, H.; Yue, Z. F.; Zhang, Z. M.; Teng, K. S.; Li, M. J.; Yi C. Q*.; Yang, M. S. “Coupling Gold Nanoparticles to Silica Nanoparticles through Disulfide Bonds for Glutathione Detection”. 2013, Nanotechnology, 24, 375501.
64.Liu, D. D.; Yi C. Q.; Fong, C. C.; Jin, Q. H.; Wang, Z. K.; Yu, W. K.; Sun, D.; Zhao, J. L.; Yang, M. S*. “Reorganization of Cytoskeleton and Transient Activation of Ca2+ Channels in Mesenchymal Stem Cells Cultured on Silicon Nanowire Arrays”. 2013, ACS Appl. Mater. Interfaces 5, 13295-13304.
65.Zhang, H.; Xu, Y.; Huang, Q. Y.; Yi, C. Q.; Xiao, T.; Li, Q. G*. “Natural phage nanoparticle- mediated real-time immuno-PCR for ultrasensitive detection of protein marker”. 2013, Chem Commun 49, 3778-3780.
发明专利：
1.易长青, 时宇鹏, 陈志华, 程鑫, 潘益, 张恒, 张肇敏，一种比率荧光纳米探针及其制备方法和应用，中国发明专利号：201410217964.1
2.易长青, 张恒, 时宇鹏, 张肇敏, 潘益, 蒋庆，一种基于核酸酶信号放大的超灵敏检测方法，中国发明专利号：201310480961.2
3.易长青, 张肇敏, 陈俊英, 张璐璐, 时宇鹏, 潘益, 张恒，一种对葡萄糖和胆固醇同步检测的纳米生物传感器，中国发明专利号：2014103658855
4.易长青, 蒋乐伦, 宋嵘，一种基于手机平台的食品安全快速检测装置，中国发明专利号：201410843374X
5.易长青, 张亚丽, 张恒, 宋嵘, 蒋乐伦，用于抗生素检测的纳米传感器及其制备方法和应用，中国发明专利号：2014108495360
6.张恒, 易长青, 林燕奎, 刘慧玲，荧光纳米探针及其制备方法和用于食品中多种危害因子同步检测的方法，中国发明专利号：201510833301.7
7.易长青, 潘益, 方雅宁，一种用于荧光‑磁共振双模态靶向生物成像的造影剂及其制备方法，中国发明专利号：201610727838.X
8.易长青, 刘忠刚, 蒋乐伦, 叶睿, 许树佳, 陈琼燕，基于移动智能终端的吸收和荧光光谱检测装置，中国发明专利号：201710245312.2
9.易长青, 贾军, 方雅宁，MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途，中国发明专利号：201710659485.9
10.蒋乐伦，王天云，易长青，一种电化学发光检测装置，中国发明专利号：201810816344.8
11.蒋乐伦，王天云，易长青，高洁，基于微针阵列的血糖电化学传感器，中国发明专利号：201811048417.X
12.易长青，陈璇，马俊平，一种可用于类风湿性关节炎的诊疗一体化纳米探针的制备及应用，中国发明专利号：202110386650.4
书本章节：
1.Yi C. Q*.; Pan, Y.; Fang, Y. N. “Surface Engineering of Carbon Nanodots (C-Dots) for Biomedical Applications”. 2018, In Novel Nanomaterials for Biomedical, Energy and Environmental Applications. pp137-188, Elsevier; Edited by Wang X. R. and Chen X.
学术与社会服务
1.《Chinese Chemical Letters》（中国化学快报）通讯编委
2.《Frontiers in Chemistry》Associate Editor
3.广东省知识产权局知识产权专家库入库专家
4.广东省生物医学工程学会传感技术专业委员会第三届、第四届常委
5.广东省重大行政决策咨询论证专家
6.广东省科技厅“企业科技特派员”
