刘杰
刘杰 教授/博导/院长助理
中山大学 生物医学工程学院
广东省深圳市光明区中山大学医学园2栋
中山大学教授/博导，生物医学工程学院院长助理，美国耶鲁大学博士，广东省青年拔尖人才、深圳市鹏城学者B类、广州市珠江科技新星，中国生物材料学会再生医学材料分会委员、中国生物材料学会生物材料先进制造分会委员、广东省生物医学工程学会理事兼副秘书长、广东省精准医学会类器官与器官芯片分会副主委、广东省精准医学会精准医美分会副主委。主持包括国家科技部重点研发、国家自然科学基金面上项目、广东省科技厅国际合作项目等20余项课题，在Nature Materials、Advanced Science、Biomaterials、ACS Nano等国际著名杂志发表研究论文80余篇，单篇论文引用最高350余次；获授权专利10余项，成果转化2项。研究方向包括：类器官与器官芯片；纳米材料用于药物递送和基因治疗；干细胞与再生医学。
一、学习、工作履历 （时间由近及远）
2021.02至今 中山大学生物医学工程学院 生物医学工程 教授
2016.08-2017.08 美国耶鲁大学医学院 神经外科与生物医学工程 访问学者
2014.06-2021.01 中山大学生物医学工程学院 生物医学工程 副教授
2010.10-2014.05 中山大学工学院 生物医学工程 “百人计划”讲师
2007.10-2009.10 美国耶鲁大学工学院 生物医学工程 博士
2007.01-2010.09 华中科技大学生命学院 生物材料与组织工程 博士
2004.09-2006.12 华中科技大学生命学院 生物医学工程 硕士
2000.09-2004.07 华中科技大学生命学院 生物医学工程 学士
二、研究方向
1.靶向纳米药物递送体系：针对恶性肿瘤治疗，采用合成高分子材料或外泌体等，开发系列能够用于癌症治疗的纳米药物、诊疗一体化体系，为肿瘤的靶向治疗提供新的方法和策略；
2.类器官与器官芯片：基于肿瘤、正常组织等类器官，结合3D打印、微流控技术以及类器官技术，开发能够用于药物或纳米材料评价的体外类组织器官。
3.干细胞与再生医学：基于改性生物材料构建可用于组织粘附、止血、修复的先进水凝胶体系、干细胞水凝胶体系以及3D生物打印水凝胶体系等。
4.科研项目
作为项目负责人(PI)主持的科研项目：
[1].国家重点研发计划，2023-2027
[2].深圳市科创委重点项目，2023-2025
[3].广东省自然科学基金面上项目，2022-2024
[4].国家自然科学基金面上项目，2018-2021
[5].深圳市基础研究专项面上项目，2020-2023
[6].广东省自然科学基金研究团队项目，2015-2020
[7].广东省科技计划国际合作项目，2015-2017
5.代表性论文
[1].Jiangbing Zhou, Jie Liu(共同第一作者), Christopher J. Cheng, Toral R. Patel, Caroline E.Weller, Joseph M. Piepmeier, Zhaozhong Jiang and W. Mark Saltzman*. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nature Materials, 2012, 11: 82-90
[2].Rui Dai, Wei Chen, You Chen, Jinlong Jin, Shiwei Zhang, Changhua Zhang∗ and Jie Liu∗, 3D bioprinting platform development for high-throughput cancer organoid models construction and drug evaluation. Biofabrication, 2024, 16, 035026
[3].Yongchun Li, You Chen, Yifan Xue, Jinlong Jin, Yixin Xu, Weian Zeng, Jie Liu* and Jingdun Xie*. Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia. Advanced Science, 2024, 2309482
[4].Yifan Xue, Kaijin Chen, You Chen, Yadong Liu, Junjie Tang, Xiaoge Zhang, and Jie Liu*, Engineering Diselenide-IR780 Homodimeric Nanoassemblies with Enhanced Photodynamic and Immunotherapeutic Effects for Triple-Negative Breast Cancer Treatment. ACS Nano, 2023, 17, 22, 22553–22570
[5].Lili Cheng, Peng Zhang, Yadong Liu, Zhuoyin Liu, Junjie Tang, Langtao Xu, Jie Liu*, Multifunctional hybrid exosomes enhanced cancer chemo-immunotherapy by activating the STING pathway. Biomaterials, 2023, 301, 122259
[6].Bowen Zheng, Peng Zhang, Qijun Lv, Tao Wu, Yadong Li, Junjie Tang, Yanping Ma, Lili Cheng, Langtao Xu, Yizhen Wang, Yifan Xue, Jie Liu*, Jie Ren*. Development and preclinical evaluation of multifunctional hydrogel for precise thermal protection during thermal ablation. Bioactive Materials, 2024, 31, 119–135
[7].Qijun Lv, Yizhen Wang, Zhiyong Xiong, Yifan Xue, Jiajun Li, Moyang Chen, Kaijian Zhou, Hetao Xu, Xiaoge Zhang, Jie Liu∗, Jie Ren∗, Bo Liu∗, Microvascularized tumor assembloids model for drug delivery evaluation in colorectal cancer-derived peritoneal metastasis，Acta Biomaterialia，2023, 168, 346–360
[8].Baizhu Chen, Xiaoge Zhang, Lili Cheng, Xiaomei Chen, Junjie Tang, Peng Zhang, Chen Wang, Jie Liu*. Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy. Journal of Controlled Release, 2023, 353, 889–902
[9].You Chen, Yifan Xue, Langtao Xu, Weilin Li, Yiling Chen, Shunan Zheng, Rui Dai, Jie Liu*. Recapitulation of dynamic nanoparticle transport around tumor using a triangular multi-chamber tumor-on-a-chip. Lab on a Chip, 2022, 22, 4191 - 4204
[10].Langtao Xu, You Chen, Peng Zhang, Junjie Tang, Yifan Xue, Hongsheng Luo, Rui Dai, Jinlong Jin and Jie Liu*. 3D printed heterogeneous hybrid hydrogel scaffolds for sequential tumor photothermalchemotherapy and wound healing. Biomaterials Science, 2022, 10, 5648-5661
[11].You Chen, Langtao Xu, Weilin Li, Wanqi Chen, Qiubei He, Xiaoge Zhang, Junjie Tang, Yizhen Wang, Bo Liu and Jie Liu*. 3D bioprinted tumor model with extracellular matrix enhanced bioinks for nanoparticle evaluation. Biofabrication, 2022, 14, 025002
[12].JunJie Tang, Xiaoge Zhang, Lili Cheng, Yadong Liu, You Chen, Zhaozhong Jiang**, Jie Liu*. Multiple stimuli-responsive nanosystem for potent, ROS-amplifying, chemo-sonodynamic antitumor therapy. Bioactive Materials, 2022, 15, 355-371
[13].Xiaoge Zhang, Lili Cheng, Yao Lu, Junjie Tang, Qijun Lv, Xiaomei Chen, You Chen, Jie Liu*. A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy. Nano-Micro Letters, 2022, 14, 22
[14].Lili Cheng, Xiaoge Zhang, Junjie Tang, Qijun Lv, Jie Liu*, Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy. Biomaterials, 2021, 275, 120964
[15].Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang*, Jie Liu*. Tumor microenvironment triple-responsive nanoparticles enable enhanced tumor penetration and synergetic chemo-photodynamic therapy. Biomaterials, 2021, 268, 120574
[16].Xiaoge Zhang, Junjie Tang, Chao Li, Yao Lu, Lili Cheng, Jie Liu*. A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy. Bioactive Materials, 2021, 6(2), 472-489
[17].You Chen, Weilin Li, Chao Zhang, Zhaoying Wu* and Jie Liu*. Recent Developments of Biomaterials for Additive Manufacturing of Bone Scaffolds. Advanced Healthcare Materials, 2020, 9(23), 2000724
[18].Qijun Lv, Lili Cheng, Yao Lu, Xiaoge Zhang, Yizhen Wang, Junfeng Deng, Jiangbing Zhou,* Bo Liu,* and Jie Liu*. Thermosensitive Exosome–Liposome Hybrid Nanoparticle-Mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer. Advanced Science, 202000515, 1-13
[19].Shuting Xiao, Yao Lu, Miao Feng, Ming Dong, Zhong Cao, Xiaoge Zhang, You Chen, Jie Liu*. Multifunctional FeS2 theranostic nanoparticles for photothermal-enhanced chemodynamic/photodynamic cancer therapy and photoacoustic imaging. Chemical Engineering Journal, 2020, 396, 125294
