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郭剑和

  

 

 

姓名:郭剑和

职称:副教授/硕士生导师

邮箱:guojianhe@mail.sysu.edu.cn

 

主要经历:

2019/06-现在:中山大学,生物医学工程,百人计划助理教授、副教授

2018/09-2019/05:德克萨斯大学奥斯汀分校,材料科学与工程,博士后研究员

2012/09-2018/08:德克萨斯大学奥斯汀分校,材料科学与工程,博士

                                导师:范冬蕾 教授(美国医学与生物工程院院士)

2008/09-2012/06:中国科学技术大学,材料化学,学士

                               导师:杨上峰 教授

 

研究简介:

本课题组隶属于戴宗教授领衔的生化传感与生物分析研究团队,团队面向体外诊断及分子检测临床需求,聚焦功能微纳生物材料、生物医学检测技术、微纳生物传感器件以及医学检测集成系统开展创新性研究,推动生物医学传感原理和核心传感技术装置的研发和转化。

在该研究方向下,本课题组聚焦拉曼光谱检测、微纳机器人与微纳操控、纳米生物传感、和微流体芯片等技术,主要应用在精子筛选、肿瘤筛查、术中诊断等医学检测领域。本课题组相关科研成果及其生物医学应用2014年被英国广播公司BBC Focus杂志评为将会改变未来的十大发明 (10 discoveries that will shape the future)”2015年入围美国西南偏南(SXSW)盛典的互动创新奖2016美国国家科学基金会NSF联合美国国家广播公司NBC进行特别专访,并录制科教片纳米技术: 超小尺度科学

拉曼光谱临床应用的科普简介:

http://www.sinospectroscopy.org.cn/readnews.php?nid=45234

微纳机器人的科普简介:

https://www.guokr.com/article/454947/(其中包含本课题组工作)

 

招生信息:

本课题组每年均有硕士研究生保研/考研的招生名额,招生面向所有生物医学工程相关专业,包括但不限于材料、化学、物理、生物、机械工程、生物工程、电子工程、生物医学工程等。

 

科研项目:

[1] 国家自然科学基金,青年项目,2022-2024,在研

[2] 广东省自然科学基金,面上项目,2023-2025,在研

[3] 广东省区域联合基金,青年项目,2021-2024,结题

[4] 深圳市优秀科技创新人才培养项目,博士基础研究启动项目,2022-2024,结题

[5] 深圳市高等院校稳定支持计划项目,面上项目,2021-2023,结题

[6] 中山大学高校基本科研业务费,青年教师培育项目,2020,结题

[7] 中山大学百人计划启动经费,2019-2022,结题

[8] 企业技术开发委托项目,上海实彦医疗科技有限公司,2023-2025,在研

 

代表论文:

[1] X. Huang, Z. Li, Y. Shi, Y. Zhang, T. Shen, M. Chen, Z. Huang, Y. Tong, S. Liu, J. Guo*, X. Zou, Z. Dai*. A DNAzyme dual-feedback autocatalytic exponential amplification biocircuit for microRNA imaging in living cells. Biosensors & Bioelectronics, 2023, 241, 115669. (IF=10.7)

[2] K. Kim#, X. Xu#, J. Guo#, D. Fan*. Ultrahigh-speed rotating nanoelectromechanical system devices assembled from nanoscale building blocks. Nature Communications, 2014, 5, 3632. (IF=14.7)

[3] J. Guo#, Z. Liang#, Y. Huang, K. Kim, P. Vandeventer, D. Fan*. Acceleration of Biomolecule Enrichment and Detection with Rotationally Motorized Opto-Plasmonic Microsensors and the Working Mechanism. ACS Nano, 2020, 14, 15204. (IF=15.8)

[4] J. Guo, J. Gallegos, A. Tom, D. Fan*. Electric-Field-Guided Precision Manipulation of Catalytic Nanomotors for Cargo Delivery and Powering Nanoelectromechanical Devices. ACS Nano, 2018, 12, 1179. (IF=15.8)

[5] X. Huang, M. Chen, Z. Huang, Y. Zhang, T. Shen, Y. Shi, Y. Tong, X. Zou, S. Liu*, J. Guo*, Z. Dai*. On-Site-Activated Transmembrane Logic DNA Nanodevice Enables Highly Specific Imaging of Cancer Cells by Targeting Tumor-Related Nucleolin and Intracellular MicroRNA. Analytical Chemistry, 2023, 95, 14746. (IF=6.7)

[6] X. Huang, Z. Li, Y. Tong, Y. Zhang, T. Shen, M. Chen, Z. Huang, Y. Shi, S. Wen, S. Liu, J. Guo*, X. Zou, Z. Dai*. DNAzyme-Amplified Cascade Catalytic Hairpin Assembly Nanosystem for Sensitive MicroRNA Imaging in Living Cells. Analytical Chemistry, 2023, 95, 11793. (IF=6.7)

[7] T. Shen, X. Huang, Y. Zhang, Y. Tong, Y. Shi, J. Guo*, X. Zou*, Y. Xu*, Z. Dai*. Dephosphorylation Switch DNAzyme-RCA Circuit: A Robust Strategy for the Homogeneous and Reliable Detection of FTO Demethylase. Analytical Chemistry, 2023, 96, 1686. (IF=6.7)

[8] Z. Yao, Y. Xiong, H. Kang, X. Xu*, J. Guo*, W. Li*, X. Xu*. Tunable Periodic Nanopillar Array for MAPbI3 Perovskite Photodetectors with Improved Light Absorption. ACS Omega, 2024, 9, 2606. (IF=4.0)

[9] J. Liu#, J. Guo#, G. Meng, D. Fan*. Superstructural Raman Nanosensors with Integrated Dual Functions for Ultrasensitive Detection and Tunable Release of Molecules. Chemistry of Materials, 2018, 30, 5256. (IF=7.2)

[10] J. Guo, A. Chan, W. Li, D. Fan*. Kirkendall Effect in Creating Three-Dimensional Metal Catalysts for Hierarchically Porous Ultrathin Graphite with Unique Properties. Chemistry of Materials, 2017, 29, 4991. (IF=7.2)

 

授权专利:

[1] D. Fan, J. Ning, X. Xu, J. Guo, "Method for Manufacturing of Three-Dimensional Freestanding Porous Thin-Graphite with Hierarchical Porosity" (US patent granted, US 14,738,301, May 2018).

[2] D. Fan, K. Kim, J. Guo, "Electrode Design and a Low-Cost Fabrication Method for Assembling and Actuation of Miniature Motors with Ultrahigh and Uniform Speed" (US patent granted, 10,944,339, March 2021).

[3] D. Fan, W. Li, J. Guo, "Flexible Supercapacitors and Devices Containing the Same" (US patent granted, 10,984,964, April 2021).

 

书籍著作:

[1] J. Guo, D. Fan, "Electromagnetic Wave Enabled Micro/nanorobotic Devices and Their Applications" Light Robotics: Structured-Mediated Nanobiophotonics, Elsevier (2017).   

[2] Z. Liang, J. Guo, D. Fan, "Manipulation, Assembling, and Actuation of Nanomotors by the Electric Tweezers", Robotic Systems and Autonomous Platforms, Elsevier (2018).