柳思扬
柳思扬，中山大学生物医学工程学院副教授，博士生导师，硕士生导师。
长期致力于基于功能材料分子工程设计构建平民化便携式快检装置与优质化传感成像技术。已发表SCI论文50余篇，其中以第一/通讯作者在Adv. Mater. (×2), Angew. Chem. Int. Ed. (×2), TrAC Trend. Anal. Chem., Anal. Chem. (×6), Chem. Eng. J (×2), Adv. Funct. Mater., Nano Lett. 等高水平期刊发表研究工作20余篇。被引3000余次，H因子23。申请专利11件，其中授权4件。担任《分析测试学报》、《Biomedical Analysis》、《Biomed. Eng. Commun.》期刊青年编委。主持2项国家级、5项省市级科研项目。
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姓名：柳思扬（Si-Yang Liu）
职称：副教授、博士生导师、硕士生导师
邮箱：liusiyang@mail.sysu.edu.cn（ORCID：https://orcid.org/0000-0001-8377-2396）
地址：广东省深圳市光明区公常路66号中山大学医学园2-501B
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主要经历：
2023/06 至今 : 中山大学生物医学工程学院，副教授，硕士生导师，博士生导师（2025/08至今）
2020/06 – 2023/06: 中山大学生物医学工程学院，特聘副研究员
2017/07 – 2020/06: 中山大学化学学院，特聘副研究员，博士后（合作导师：戴宗教授）
2014/12 – 2015/05: 新加坡南洋理工大学材料科学与工程学院访学（导师：张华教授）
2012/09 – 2017/07: 中山大学材料物理与化学专业，工学博士（导师：陈小明教授）
2008/09 – 2012/07: 中山大学应用化学专业，理学学士
研究方向:
1.便携式快检装置：基于新型多功能一体化材料（金属有机框架/二维材料/纳米金/功能核酸/酶复合材料），研发多种疾病标志物（小分子、核酸、蛋白、外泌体、细菌等）便携式即时检测装置。
2.精准传感成像技术：针对小分子、大分子（核酸/蛋白）、囊泡（外泌体）等系列疾病标志物，基于纳米技术研发高性能细胞/活体动态成像方法与装置。
主持项目:
1.国家自然科学基金面上项目，22474161，2025.1-2028.12，50万元
2.国家自然科学基金青年科学项目，21801259，2019.1-2021.12，25万元（结题）
3.广东省自然科学基金青年提升项目，2024A1515030162，2024.01-2026.12，30万元
4.广东省自然科学基金面上项目，2022A1515011318，2022.01-2024.12，10万元（结题）
5.深圳市基础研究面上项目，JCYJ20210324120601004，2021.11-2024.10，60万元（结题）
6.广东省自然科学基金自由申请项目，2018A030313290，2018.5-2021.04，10万元（结题）
7.中国博士后基金面上项目一等资助，2018M631014，2018.5-2019.5，8万元（结题）
主要兼职：
中国检验检测学会青年科技工作者委员
广东省生物医学工程学会精密科学仪器分会委员
深圳市分析测试协会生化测试专业委员会委员
《分析测试学报》, Biomedical Analysis，Biomed. Eng. Commun. 青年编委；
Inorganics, Front. Chem. 客座编辑；
Adv. Sci., TrAC-Trend. Anal. Chem., Anal. Chem., Sens. Actuators B Chem., ACS Appl. Mater. Interfaces, J. Appl. Polym. Sci., Front. Chem. 等期刊审稿人。
综述：
1.Jiaqi Huang, Jiajun Pan, Yiteng Song, Qian Lin, Yuzhi Xu,* Zong Dai,* Si-Yang Liu*. MOF-functionalized paper-based biosensors: Fabrications, mechanisms and applications. TrAC Trend. Anal. Chem., 2024, 117619. (中科院一区)
2.Xinyu You†, Renzheng He†, Si-Yang Liu*, Zong Dai*, Advances in fluorescence imaging of RNAs in living cells based on functional nucleic acid probes. Biomedical Analysis, 2024, 1, 1. (中山大学生物医学工程学院主办国产英文期刊)
3.Yiling Zhang†, Qian Lin†, Yiteng Song, Jiaqi Huang, Miaomiao Chen, Runqi Ouyang, Si-Yang Liu,* Zong Dai, MOF-Based Materials for Glucose Detection. Chemosensors 2023, 11, 429. (Invited review in Special Issue: Bionic Recognition and Biosensors: A Theme Issue in Honor of Professor Hong-Yuan Chen)
4.Si-Yang Liu, Jie-Peng Zhang,* and Xiao-Ming Chen. Cu(I) 3,5-Diethyl-1,2,4-Triazolate (MAF-2): From Crystal Engineering to Multifunctional Materials. Cryst. Growth Des., 2017, 17, 1441.
5.Rui-Biao Lin, Si-Yang Liu, Jia-Wen Ye, Xu-Yu Li, Jie-Peng Zhang.* Photoluminescent Metal–Organic Frameworks for Gas Sensing. Adv. Sci., 2016, 2016, 1500434. (中科院一区, Invited Review, Highly Cited Paper)
第一作者及通讯作者科研论文:
1.Wen Yin, Haitian Chen, Jianye Cai, Xing Huang, Lang Zhang, Yuzhi Xu, Jun Zheng,* Si-Yang Liu,* Xiaoyong Zou, Zong Dai,* Yang Yang. Isolation of Structurally Heterogeneous TCR-CD3 Extracellular Vesicle Subpopulations Using Caliper Strategy. Angew. Chem. Int. Ed. 2023, 2023954. (中科院一区)
2.Yuzhi Xu, Si-Yang Liu (co-first author), Leli Zeng,* Hansu Ma, Yanfei Zhang, Huihui Yang, Yuchen Liu, Shuo Fang, Jing Zhao, Yunsheng Xu, Charles R. Ashby Jr, Yulong He,* Zong Dai,* Yihang Pan*. Enzyme-Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis-based Synergistic Cancer Therapy. Adv. Mater., 2022, 2204733. (中科院一区, Highly cited paper)
3.Si-Yang Liu (co-first author), Yuzhi Xu, Huihui Yang, Liping Liu, Meiting Zhao, Wen Yin, Yan-Tong Xu, Ying Huang, Chaoliang Tan, Zong Dai,* Hua Zhang,* Jie-Peng Zhang,* Xiao-Ming Chen. Ultrathin 2D Copper(I) 1,2,4-Triazolate Coordination Polymer Nanosheets for Efficient and Selective Gene Silencing and Photodynamic Therapy. Adv. Mater. 2021, 2100849. (中科院一区)
4.Si-Yang Liu, Dong-Dong Zhou, Chun-Ting He, Pei-Qin Liao, Xiao-Ning Cheng, Yan-Tong Xu, Jia-Wen Ye, Jie-Peng Zhang,* and Xiao-Ming Chen. Flexible, Luminescent Metal–Organic Frameworks Showing Synergistic Solid-Solution Effects on Porosity and Sensitivity. Angew. Chem. Int. Ed. 2016, 55, 16021. (中科院一区)
5.Jiaqi Huang, Yanfei Zhang, Huiwen Wang, Yuzhi Xu, Changqing Yi, Zong Dai*, Si-Yang Liu*, MOF-Integrated Single-Enzymatic Colorimetric Paper-Based Biosensor for Point-of-Care Testing of Organophosphorus Pesticides. Anal. Chem. 2025, 97, 15402. (中科院一区)
6.Shaoqiang Wen, Lang Zhang, Zhan Huang, Meng Chen, Yuzhi Xu, Xing Huang, Zhou Zhang, Xiaoyong Zou*, Zong Dai*, Si-Yang Liu*, Aptamer&MOF-functionalized multichannel paper chip for point-of-care testing of small extracellular vesicle membrane protein profile. Chin. Chem. Lett. 2025, 111333. (中科院一区)
7.Yanfei Zhang,Yiling Zhang, Runqi Ouyang, Zong Dai*, Si-Yang Liu*, A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells. Chemosensors, 2025, 13, 123.
8.Zhan Huang, Xing Huang, Yanfei Zhang, Meng Chen, Shaoqiang Wen, Zhou Zhang, Zong Dai,* Xiaoyong Zou,* Si-Yang Liu*, A chirality/microRNA dual-gating theranostic nanomachine for gene silencing therapy. Chem. Eng. J. 2024, 497, 154618. (中科院一区)
9.Yanli Tong, Meng Chen, Xing Huang, Yuzhi Xu, Lang Zhang, Zhenning Yu, Si-Yang Liu,* Zong Dai* Aptasensor based on gold nanostructure-decorated 2D Cu metal–organic framework nanosheets for highly sensitive and specific electrochemical lipopolysaccharide detection. Microchim. Acta 2024, 191, 500.
10.Xing Huang, Meng Chen, Zhan Huang, Yanfei Zhang, Taorong Shen, Yakun Shi, Yanli Tong, Xiaoyong Zou, Si-Yang Liu,* Jianhe Guo,* and Zong Dai* On-Site-Activated Transmembrane Logic DNA Nanodevice Enables Highly Specific Imaging of Cancer Cells by Targeting Tumor-Related Nucleolin and Intracellular MicroRNA. Anal. Chem. 2023, 95, 14746. (中科院一区)
11.Qian Lin, Jiaqi Huang, Yiling Zhang, Miaomiao Chen, Yuzhi Xu, Xiaoyong Zou, Si-Yang Liu,* Zong Dai. A Smartphone-Assisted “All-in-One” Paper Chip for One-Pot Noninvasive Detection of Salivary Glucose Level. Chem. Eng. J. 2023, 468, 143608. (中科院一区)
12.Wen Yin, Yanfei Zhang, Yuling Liang, Hui-Hui Yang, Yuzhi Xu, Si-Yang Liu*, Jianhua Zhou*, Zong Dai*, and Xiaoyong Zou. NanoSuit-Assisted Liquid-Cell Scanning Electron Microscopy Enables Dynamic Gold Nanoparticle Monitoring for the Aggregation and Transmembrane Processes in Living Cells. Nano Lett. 2022, 22, 5788. (中科院二区TOP)
13.Xing Huang, Yanfei Zhang, Jun Chen, Lang Zhang, Yuzhi Xu, Wen Yin, Yakun Shi, Si-Yang Liu*, Xiaoyong Zou, and Zong Dai*. Dual-Locked DNAzyme Platform for In Vitro and In Vivo Discrimination of Cancer Cells. Anal. Chem. 2022, 94, 12221. (中科院一区)
14.Lang Zhang, Wen Yin, Yanli Tong, Yanfei Zhang, Yuzhi Xu, Si-Yang Liu*, Zong Dai*, and Xiaoyong Zou. Highly Efficient Isolation and Sensitive Detection of Small Extracellular Vesicles Using a Paper-Based Device. Anal. Chem. 2022, 94, 31, 10991. (中科院一区, Cover paper)
15.Yanfei Zhang, Jun Chen, Huihui Yang, Wen Yin, Chunrong Li, Yuzhi Xu, Si-Yang Liu*, Zong Dai*, and Xiaoyong Zou*. Light-Controlled Recruitable Hybridization Chain Reaction on Exosome Vehicles for Highly Sensitive MicroRNA Imaging in Living Cells. Anal. Chem. 2022, 94, 9665. (中科院一区)
16.Huihui Yang, Yanfei Zhang, Leli Zeng, Wen Yin, Yuzhi Xu,* Jun Chen, Si-Yang Liu,* Xiaoyong Zou, Zhiyu He, Zong Dai*. Cell-Selective Encapsulation within Metal–Organic Framework Shells via Precursor-Functionalized Aptamer Identification for Whole-Cell Cancer Vaccine. Small Methods 2022, 6, 2101391. (中科院二区)
17.Lang Zhang, Jun Chen, Huihui Yang, Zhenning Yu, Yuzhi Xu, Si-Yang Liu,* Zong Dai,* Xiaoyong Zou. A Chromogenic Reaction-Free Distance-Based Paper Device for Facile Detection of microRNA via Viscosity Amplification and Surface Hydrophobicity Modulation. Sens. Actuators B Chem. 2022, 359, 131570. (中科院一区)
18.Yuzhi Xu, Yanfei Zhang, Huihui Yang, Wen Yin, Leli Zeng, Shuo Fang, Si-Yang Liu,* Zong Dai,* Xiaoyong Zou, Yihang Pan*. Two-dimensional coordination polymer-based nanosensor for sensitive and reliable nucleic acids detection in living cells. Chin. Chem. Lett. 2022, 33, 968. (中科院一区)
19.Yuling Liang, Huihui Yang, Wen Yin, Yanfei Zhang, Yuzhi Xu, Si-Yang Liu*, Zong Dai*, Xiaoyong Zou. Long-Term Continuous Monitoring of microRNA in Living Cells Using Modified Gold Nanoprobe. Anal. Bioanal. Chem. 2022, 414, 6157.
20.Huihui Yang, Jun Chen, Yuling Liang, Yanfei Zhang, Wen Yin, Yuzhi Xu, Si-Yang Liu,* Zong Dai,* and Xiaoyong Zou. A MOF-Shell-Confined I-Motif-Based pH Probe (MOFC-i) Strategy for Sensitive and Dynamic Imaging of Cell Surface pH. ACS Appl. Mater. Interfaces 2021, 13, 45291.
21.Yuzhi Xu, Si-Yang Liu (co-first author), Junling Liu, Li Zhang, Danping Chen, Jun Chen, Yingjun Ma, Jie-Peng Zhang,* Zong Dai,* and Xiaoyong Zou. In Situ Enzyme Immobilization with Oxygen-Sensitive Luminescent Metal–Organic Frameworks to Realize “All-in-One” Multifunctions. Chem.-Eur. J., 2019, 25, 5463. (Cover paper)
22.Yuzhi Xu, Si-Yang Liu (co-first author), Jie Li, Li Zhang, Danping Chen, Jie-Peng Zhang* , Yanhui Xu, Zong Dai* , and Xiaoyong Zou. Real-Time Sensing of TET2-Mediated DNA Demethylation In Vitro by Metal–Organic Framework-Based Oxygen Sensor for Mechanism Analysis and Stem-Cell Behavior Prediction. Anal. Chem. 2018, 90, 9330. (中科院一区)
23.Si-Yang Liu, Xiao-Lin Qi, Rui-Biao Lin, Xiao-Ning Cheng, Pei-Qin Liao, Jie-Peng Zhang* and Xiao-Ming Chen. Porous Cu(I) Triazolate Framework and Derived Hybrid Membrane with Exceptionally High Sensing Efficiency for Gaseous Oxygen. Adv. Funct. Mater. 2014, 24, 5866. (中科院一区, Back cover paper)
教学教改：
1.基于核酸检测全流程的《仪器分析实验》课程设计，2025年校级教学质量与教学改革工程项目，主持，1万元。
2.柳思扬*，李勇科，许宇智，潘逸航，戴宗*，理论联系实际的综合性核酸检测实验课程设计——聚合酶链式反应及环介导等温扩增用于新冠病毒核酸检测，《分析测试学报》，2025，44(7)，1443。
著作章节：
1.Zong Dai, Li Zhang, Si-Yang Liu, Yuzhi Xu, Danping Chen, Jun Chen, Xiaoyong Zou, in DNA Modification Detection Methods (Editor: Yuan, Bi-Feng), Springer US, New York, NY, 2022, 53.
专利：
1.柳思扬，王雨欣，温少强，刘雅婷，戴宗，邹小勇，一种多通道纸芯片装置及其在小细胞外囊泡膜蛋白检测中的应用，中国发明专利，CN119936379A
2.柳思扬，林蒨，戴宗，邹小勇，一种一体化无创式唾液葡萄糖检测试纸的制备及其应用，中国发明专利，CN116858823A
3.戴宗，梁玉玲，柳思扬，邹小勇，一种用于活细胞miRNA连续成像监测的荧光探针，中国发明专利，CN114480646A
4.戴宗，殷文，柳思扬，邹小勇，杨扬，陈海填，一种分离细胞外囊泡亚群的方法及其应用，中国发明专利，CN114457002A（已授权）
5.戴宗，杨慧慧，柳思扬，邹小勇，一种肿瘤全细胞靶向试剂及其制备方法及应用，中国发明专利，CN113648404A（已授权）
6.张杰鹏，柳思扬，洪慧玲，陈小明，一种多孔配合物复合薄膜氧气传感器及其制备方法，中国发明专利，CN103822909A.（已授权）
7.戴宗，许宇智，柳思扬，张杰鹏，邹小勇，一种一体化颗粒型固定化酶生物传感器及其制备方法和应用，中国发明专利，CN109030802A（已授权）
会议:
2025/8，第三届广西有机化学会议，桂林，邀请报告
2024/7，2024分析测试前沿论坛，贵阳，口头报告
2024/4，中西部地区无机化学化工学术研讨会，海口，口头报告
2024/4，2024武汉分析+国际峰会，武汉，口头报告
2024/3，中国化学会第八届“菁青论坛”，合肥，口头报告
2023/11: 第二十二届全国有机分析及生物分析学术研讨会，揭阳，邀请报告
2023/11: 2023分析测试高峰论坛，广州，邀请报告
2023/11: 第十四届全国分析化学年会，深圳，口头报告
2023/9: 第十六届全国化学传感器学术会议，济南，口头报告
2023/8: 中国化学会第十一届全国无机化学学术会议，兰州，口头报告
2023/5: 中国化学会第33届学术年会，青岛，口头报告
2023/4: 第八届全国结构化学学术会议，福州，邀请报告
2020/4: 第十三届全国微全分析系统学术会议，深圳，口头报告
2019/8: 第十届全国无机化学学术会议，济南，海报展示（优秀海报奖）
2019/8: 第十六届全国应用化学年会，乌鲁木齐，海报展示（优秀海报奖）
2017/8: 24th Congress and General Assembly of the International Union of Crystallography，印度海得拉巴，海报展示
2017/7: The 6th Asian Conference on Coordination Chemistry，澳大利亚墨尔本，海报展示
2014/9: 4th International Conference on Metal-Organic Frameworks and Open Framework Compounds，日本神户，海报展示
获得奖项:
2019/01: 学院优秀工会工作者
2016/10: 研究生国家奖学金
2017/10: 芙兰优秀论文奖一等奖
2014/10: 芙兰优秀论文奖一等奖
2013/10: 金发科技奖学金
招生与招聘:
生物分析与生化传感团队
Biomedical and Chemical Sensing Lab
l本课题组（团队负责人：戴宗教授）长期招聘具有较好生物医学传感、检测装置研发及相关研究背景的博士后和副研究员。
l欢迎具有生物医学工程、化学、生物、材料、微流控及相关背景的同学报考课题组研究生。
l欢迎各年级本科生加入本课题组，开展科研训练、创新创业及毕业设计。
l本课题组与香港大学、香港理工大学、香港城市大学、香港中文大学、德州大学奥斯汀分校、南京大学等海内外高校课题组紧密合作，可择优选派或推荐课题组优秀成员前往以上学校交流访学。
l请感兴趣者邮件联系 liusiyang@mail.sysu.edu.cn，并附个人简历。
