乐志成
乐志成，中山大学副教授，博士生导师。2021年于中山大学获博士学位。主要从事生物医学材料研究，并针对肿瘤、糖尿病创面、耐药细菌感染等重大临床疾病需求开发蛋白质治疗、基因治疗和噬菌体疗法。迄今以（共同）第一作者/通讯作者在Advanced Materials、Advanced Functional Materials、ACS Central Science、Materials Today、和Biomaterials等国际知名学术期刊发表学术论文10余篇。获授权6项中国发明专利，申请3项国际专利。（曾）担任Chinese Chemical Letters和Smart Molecules期刊青年编委，Nanoscale Advances和Pharmaceuticals期刊客座编辑。
个人信息（Personal Information）
姓名（Name）：乐志成（Le, Zhicheng）
职称（Title）：副教授/博士生导师（Associate Professor）
电子邮箱（E-mail）： lezhicheng@mail.sysu.edu.cn
地址（Office）：广东省深圳市光明区公常路66号，中山大学深圳校区医学园2-418
教育工作经历（Education & Working Experience）
2025.02至今：中山大学，生物医学工程学院，副教授
2021.08−2025.02：新加坡国立大学，生物医学工程系/医疗健康创新与科技研究院，Research Fellow
2016.09−2021.06：中山大学，材料物理与化学，博士
2012.09−2016.06：海南大学，高分子材料与工程，学士
研究方向（Research Interests）
大分子药物递送：致力于开发两亲性小分子组装体、脂质纳米颗粒及类肽聚合物等递送载体，解决蛋白质与核酸等生物大分子药物易降解及跨细胞膜屏障能力差的挑战，提升其生物利用度与治疗效果。
噬菌体递送与控释：针对噬菌体疗法在临床应用中所面临的半衰期短、生物膜穿透困难及深部感染组织递送受限等瓶颈，设计并构建水凝胶、微针等给药系统提升噬菌体抗菌功效，推动其转化应用。
主持科研项目（Research Funding）
1.国家自然科学基金，青年科学基金项目（C类）, 2026.01–2028.12
2.广东省自然科学基金，优秀青年项目，2026.01–2028.12
3.中山大学引进人才基本启动费，2025.04–2028.12
论著（Publications）
期刊论文（近五年，*通讯作者，#同等贡献作者）
1 Zhicheng Le; Sevugan Mayalagu; Cheng-Yen Chen; Raktim Bhattacharya; Abhishek Gupta; Jingyuan Li; Zhi Wei Norman Teo; Yufeng Shou; Arya Gopinath MP; Danni Zhong; Tedrick Thomas Salim Lew; Hao Yu; Naweed I. Naqvi; Sanjay Swarup; Andy Tay* Microneedle-based biofertilizer delivery improves plant growth through microbiome engineering. Advanced Functional Materials 2026, 36, e22554.
2 Lili Cheng; Dan Peng; Zhuoyin Liu; Junjie Tang; Peng Zhang; Meiqi Li; Jing Li; Zhicheng Le*; Jie Liu* Engineered bacterial outer membrane vesicles enhanced tumor immunotherapy through remodeling tumor stroma and targeted delivery of CD73 siRNA. Biomaterials 2026, 327, 123725.
3 Zepeng He#; Zhicheng Le#; Zhijia Liu*; Yongming Chen* Multicomponent reaction-based combinatorial chemistry for accelerating the discovery of therapeutic protein and nucleic acid delivery materials. NPG Asia Materials 2025, 17, 14.
4 Zhicheng Le#; Mayk Caldas Ramos#; Yufeng Shou; Renee R. Li; Hong Sheng Cheng; Clarisse J. M. Jang; Ling Liu; Chencheng Xue; Xianlei Li; Hong Liu; Chwee Teck Lim; Nguan Soon Tan; Andrew D. White; Christopher John Charles; Yongming Chen; Zhijia Liu*; Andy Tay* Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors. Biomaterials 2024, 311, 122700.
5 Zhicheng Le; Yufeng Shou; Renee R Li; Ling Liu; Runcheng Tan; Christopher John Charles; Zhijia Liu; Yongming Chen*; Andy Tay* Sponge-like microneedles spatially sequester chemokines and deplete monocytes to alleviate inflammatory skin disorders. Advanced Functional Materials 2024, 34, 2402539.
6 Zhicheng Le#; Jiang Qian#; Haolin Chen#; Zepeng He; Runcheng Tan; Hong Liu; Zhenfu Wen; Yi Shi; Zhijia Liu*; Yongming Chen* A versatile gemini amphiphile-based platform with STING-activating properties for efficient gene delivery into dendritic cells. Chemical Engineering Journal 2024, 497, 154513.
7 Kenny Zhuoran Wu#; Zhicheng Le#; Ba Myint; Brian Chan; Ling Liu; Hua Huang; Swee Leong Sing; Andy Tay* Bioactive coating provides antimicrobial protection through immunomodulation and phage therapeutics. Materials Today Bio 2024, 26, 101022.
8 Yufeng Shou#; Zhicheng Le#; Hong Sheng Cheng; Qimin Liu; Yi Zhen Ng; David Laurence Becker; Xianlei Li; Ling Liu; Chencheng Xue; Natalie Jia Ying Yeo; Runcheng Tan; Jessalyn Low; Arun R.K. Kumar; Kenny Zhuoran Wu; Hua Li; Christine Cheung; Chwee Teck Lim; Nguan Soon Tan; Yongming Chen; Zhijia Liu*; Andy Tay* Mechano-activated cell therapy for accelerated diabetic wound healing. Advanced Materials 2023, 35, 2304638.
9 Zhicheng Le#; Qi Pan#; Zepeng He; Hong Liu; Yi Shi; Lixin Liu; Zhijia Liu*; Yuan Ping*; Yongming Chen* Direct cytosolic delivery of proteins and CRISPR-Cas9 genome editing by Gemini amphiphiles via non-endocytic translocation pathways. ACS Central Science 2023, 9, 1313–1326.
10 Zhicheng Le; Jinming Yu; Ying Jie Quek; Bingyu Bai; Xianlei Li; Yufeng Shou; Ba Myint; Chenjie Xu; Andy Tay* Design principles of microneedles for drug delivery and sampling applications. Materials Today 2023, 63, 137–169.
11 Siying Chen#; Zhicheng Le#; Jiayue Gu; Lixin Liu; Zhijia Liu*; Yongming Chen* Exploring the effect of amphiphile architecture on intracellular protein delivery capacity: dimeric versus trimeric amphiphiles. ACS Applied Materials & Interface 2023, 15, 26328–26339.
12 Zhicheng Le; Zepeng He; Hong Liu; Jia Ke; Lixin Liu; Zhijia Liu*; Yongming Chen* Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases. Biomaterials Science 2022, 10, 4156–4169.
13 Zhicheng Le; Zepeng He; Hong Liu; Lixin Liu; Zhijia Liu*; Yongming Chen* Antioxidant enzymes sequestered within lipid–polymer hybrid nanoparticles for the local treatment of inflammatory bowel disease. ACS Applied Materials & Interface 2021, 13, 55966–55977.
完整论文列表：https://www.x-mol.com/groups/nanomed_advfab/people/96541
荣誉奖项（Awards）
1.2024.12.12, IFMBE Young Investigators Award at the 18th International Conference on Biomedical Engineering (ICBME 2024), Singapore.
2.2024.12.06, International Travel Award at the 15th BSRT Symposium 2024, Berlin, Germany
招聘与招生（Join Us）
课题组长期招聘具有化学、材料、生物、医学和药学相关背景的特聘副研究员及博士后；欢迎报考课题组硕士和博士研究生；欢迎本科生加入课题组开展科研训练和毕业设计。
