乐志成

个人信息（Personal Information）

姓名（Name）：乐志成（Le, Zhicheng）

职称（Title）：副教授/博士生导师（Associate Professor）

电子邮箱（E-mail）： lezhicheng@mail.sysu.edu.cn

地址（Office）：广东省深圳市光明区公常路66号，中山大学深圳校区医学园2-418

 

工作经历（Working Experience）

2025.02至今：中山大学，生物医学工程学院，副教授

2021.08−2025.02：新加坡国立大学，生物医学工程系/医疗健康创新与科技研究院，Research Fellow

 

教育经历（Education）

2016.09−2021.06：中山大学，材料物理与化学，博士

2012.09−2016.06：海南大学，高分子材料与工程，学士

 

研究方向（Research Interest）

细胞内药物递送技术：聚焦两亲性分子组装体、脂质纳米颗粒、刺激响应型聚合物的协同递送体系构建，解决生物大分子药物的膜屏障穿透难题。通过理性设计载体材料的拓扑结构与动态响应特性，突破蛋白质、核酸药物及基因编辑工具的靶向递送瓶颈。

诊疗微针系统：面向组织再生医学与肿瘤个体化治疗需求，开发基于新材料/新设计的微针体系高效给药，发展微创、可持续和原位生物信息捕获功能的微针平台，实现"治疗-监测-反馈"闭环调控的个性化医疗新模式。

 

 

论著（Publications）

期刊论文（*为通讯作者，#为同等贡献作者）

1.Z. Le, Y. Shou, R.R. Li, L. Liu, R. Tan, C.J. Charles, Z. Liu, Y. Chen*, A. Tay*, Sponge-like microneedles spatially sequester chemokines and deplete monocytes to alleviate inflammatory skin disorders, Adv. Funct. Mater. 2024, 2402539.

2.Z. Le^#, M.C. Ramos^#, Y. Shou, R.R. Li, H.S. Cheng, C.JM. Jang, L. Liu, C. Xue, X. Li, H. Liu, C.T. Lim, N.S. Tan, A.D. White, C.J. Charles, Y. Chen, Z. Liu*, A. Tay*, Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors, Biomaterials 2024, 311, 122700.

3.Z. Le^#, J. Qian^#, H. Chen^#, Z. He, R. Tan, H. Liu, Z. Wen, Y. Shi, Z. Liu*, Y. Chen*, A versatile gemini amphiphile-based platform with STING-activating properties for efficient gene delivery into dendritic cells, Chem. Eng. J. 2024, 497, 154513.

4.K.Z. Wu^#, Z. Le^#, B. Myint, B. Chan, L. Liu, H. Huang, S.L. Sing, A. Tay, Bioactive coating provides antimicrobial protection through immunomodulation and phage therapeutics, Mater. Today Bio 2024, 26, 101022.

5.Y. Shou^#, Z. Le^#, H.S. Cheng, Q. Liu, Y.Z. Ng, D.L. Becker, X. Li, L. Liu, C. Xue, N.J.Y. Yeo, R. Tan, J. Low, A.R.K. Kumar, K.Z. Wu, H. Li, C. Cheung, C.T. Lim, N.S. Tan, Y. Chen, Z. Liu*, A. Tay*, Mechano-activated cell therapy for accelerated diabetic wound healing, Adv. Mater. 2023, 2304638. (Q1, IF = 27.4). Featured by The Straits Times, Zaobao, NUS News, and 20+ international media outlets.

6.Z. Le^#, Q. Pan^#, Z. He, H. Liu, Y. Shi, L. Liu, Z. Liu*, Y. Ping*, Y. Chen*, Direct cytosolic delivery of proteins and CRISPR-Cas9 genome editing by Gemini amphiphiles via non-endocytic translocation pathways, ACS. Cent. Sci. 2023, 9, 1313–1326.

7.S. Chen^#, Z. Le^#, J. Gu, L. Liu, Z. Liu*, Y. Chen*, Exploring the effect of amphiphile architecture on intracellular protein delivery capacity: dimeric versus trimeric amphiphiles, ACS Appl. Mater. Interfaces 2023, 15 (22), 26328–26339.

8.Z. Le, J. Yu, Y. J. Quek, B. Bai, X. Li, Y. Shou, B. Myint, C. Xu, A. Tay*, Design principles of microneedles for drug delivery and sampling applications, Mater. Today 2023, 63, 137–169.

9.Z. Le, Z. He, H. Liu, J. Ke, L. Liu, Z. Liu*, Y. Chen*, Orally administrable polyphenol-based nanoparticle achieves anti-inflammation and antitumor treatment of colon diseases, Biomater. Sci. 2022, 10 (15), 4156–4169.

10.Z. Le, Z. He, H. Liu, L. Liu, Z. Liu*, Y. Chen*, Antioxidant enzymes sequestered within lipid-polymer hybrid nanoparticles for local treatment of inflammatory bowel disease, ACS Appl. Mater. Interfaces 2021, 13 (47), 55966−55977.

11.Z. Le, T. Xiao, Z. Liu*, X. Liu, H. Liu, L. Liu, Y. Chen*, Combinatorial synthesis of redox-responsive cationic polypeptoids for intracellular protein delivery application, Sci. China Chem. 2020, 63 (11), 1619−1625.

12.P. Zhao^#, Z. Le^#, L. Liu*, Y. Chen*, Therapeutic delivery to the brain via the lymphatic vasculature, Nano Lett. 2020, 20 (7), 5415−5420.

13.Z. Le, Z. Liu*, L. Sun, L. Liu, Y. Chen*, Augmenting therapeutic potential of polyphenols by hydrogen-bonding complexation for the treatment of acute lung inflammation, ACS Appl. Bio Mater. 2020, 3 (8), 5202−5212.

14.Z. Le, Y. Chen, H. Han, H. Tian, P. Zhao, C. Yang, Z. He, L. Liu, K. W Leong, H.-Q. Mao, Z. Liu*, Y. Chen*, Hydrogen-bonded tannic acid-based anticancer nanoparticle for enhancement of oral chemotherapy, ACS Appl. Mater. Interfaces 2018, 10 (49), 42186−42197.

 

荣誉奖项（Awards）

1.2024.12.12, IFMBE Young Investigators Award at the 18th International Conference on Biomedical Engineering (ICBME 2024), Singapore.

2.2024.12.06, International Travel Award at the 15th BSRT Symposium 2024, Berlin, Germany

 

兼职与服务（Public Service）

Smart Molecules期刊青年编委，Nanoscale Advances和Pharmaceuticals期刊客座编辑。

 

招聘与招生（Join Us）

课题组长期招聘具有化学、材料、生物、医学和药学相关背景的特聘副研究员及博士后；欢迎报考课题组硕士和博士研究生；欢迎本科生加入课题组开展科研训练和毕业设计。