乐志成
乐志成，中山大学副教授，博士生导师。2021年于中山大学获博士学位，2021至2025年在新加坡国立大学从事博士后研究。主要围绕药物递送系统的“高效递送-协同作用-递送机制”关键科学问题开展研究，并针对肿瘤、糖尿病创面、耐药细菌感染等重大临床疾病需求开发蛋白质治疗、基因治疗和噬菌体疗法。迄今以（共同）第一作者/通讯作者在Advanced Materials、Advanced Functional Materials、ACS Central Science、Materials Today、和Biomaterials等国际知名学术期刊发表学术论文10余篇。获授权6项中国发明专利，申请3项国际专利。（曾）担任Chinese Chemical Letters和Smart Molecules期刊青年编委，Nanoscale Advances和Pharmaceuticals期刊客座编辑，以及Journal of Materials Chemistry B, Chinese Chemical Letters等杂志的独立审稿人。获第18届国际生物医学工程会议（ICBME 2024）青年研究员奖。
个人信息（Personal Information）
姓名（Name）：乐志成（Le, Zhicheng）
职称（Title）：副教授/博士生导师（Associate Professor）
电子邮箱（E-mail）： lezhicheng@mail.sysu.edu.cn
地址（Office）：广东省深圳市光明区公常路66号，中山大学深圳校区医学园2-418
教育工作经历（Education & Working Experience）
2025.02至今：中山大学，生物医学工程学院，副教授
2021.08−2025.02：新加坡国立大学，生物医学工程系/医疗健康创新与科技研究院，Research Fellow
2016.09−2021.06：中山大学，材料物理与化学，博士
2012.09−2016.06：海南大学，高分子材料与工程，学士
研究方向（Research Interests）
高效药物递送技术：聚焦两亲性分子组装体、脂质纳米颗粒、刺激响应型聚合物的协同递送体系构建，通过理性设计载体材料特性突破蛋白质、核酸及噬菌体的递送瓶颈。
诊疗微针系统：面向组织再生医学与肿瘤个体化治疗需求，开发基于新材料/新设计的微针体系整合高效给药与原位生物信息捕获，实现"治疗-监测-反馈"闭环调控的个性化医疗模式。
科研项目（Research Funding）
1.国家自然科学基金，青年科学基金项目（C类）, 2026.01–2028.12
2.中山大学引进人才基本启动费，2025.04–2028.12
论著（Publications）
期刊论文（*通讯作者，#同等贡献作者）
1 Zepeng He#; Zhicheng Le#; Zhijia Liu*; Yongming Chen* Multicomponent reaction-based combinatorial chemistry for accelerating the discovery of therapeutic protein and nucleic acid delivery materials. NPG Asia Materials 2025, 17, 14.
2 Kenny Zhuoran Wu#; Zhicheng Le#; Ba Myint; Brian Chan; Ling Liu; Hua Huang; Swee Leong Sing; Andy Tay* Bioactive coating provides antimicrobial protection through immunomodulation and phage therapeutics. Materials Today Bio 2024, 26, 101022.
3 Zhicheng Le#; Mayk Caldas Ramos#; Yufeng Shou; Renee R. Li; Hong Sheng Cheng; Clarisse J. M. Jang; Ling Liu; Chencheng Xue; Xianlei Li; Hong Liu; Chwee Teck Lim; Nguan Soon Tan; Andrew D. White; Christopher John Charles; Yongming Chen; Zhijia Liu*; Andy Tay* Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors. Biomaterials 2024, 311, 122700.
4 Zhicheng Le#; Jiang Qian#; Haolin Chen#; Zepeng He; Runcheng Tan; Hong Liu; Zhenfu Wen; Yi Shi; Zhijia Liu*; Yongming Chen* A versatile gemini amphiphile-based platform with STING-activating properties for efficient gene delivery into dendritic cells. Chemical Engineering Journal 2024, 497, 154513.
5 Zhicheng Le; Yufeng Shou; Renee R Li; Ling Liu; Runcheng Tan; Christopher John Charles; Zhijia Liu; Yongming Chen*; Andy Tay* Sponge-like microneedles spatially sequester chemokines and deplete monocytes to alleviate inflammatory skin disorders. Advanced Functional Materials 2024, 34, 2402539.
6 Yufeng Shou#; Zhicheng Le#; Hong Sheng Cheng; Qimin Liu; Yi Zhen Ng; David Laurence Becker; Xianlei Li; Ling Liu; Chencheng Xue; Natalie Jia Ying Yeo; Runcheng Tan; Jessalyn Low; Arun R.K. Kumar; Kenny Zhuoran Wu; Hua Li; Christine Cheung; Chwee Teck Lim; Nguan Soon Tan; Yongming Chen; Zhijia Liu*; Andy Tay* Mechano-Activated Cell Therapy for Accelerated Diabetic Wound Healing. Advanced Materials 2023, 35, 2304638.
7 Zhicheng Le#; Qi Pan#; Zepeng He; Hong Liu; Yi Shi; Lixin Liu; Zhijia Liu*; Yuan Ping*; Yongming Chen* Direct cytosolic delivery of proteins and CRISPR-Cas9 genome editing by Gemini amphiphiles via non-endocytic translocation pathways. ACS Central Science 2023, 9, 1313–1326.
8 Zhicheng Le; Jinming Yu; Ying Jie Quek; Bingyu Bai; Xianlei Li; Yufeng Shou; Ba Myint; Chenjie Xu; Andy Tay* Design principles of microneedles for drug delivery and sampling applications. Materials Today 2023, 63, 137–169.
9 Siying Chen#; Zhicheng Le#; Jiayue Gu; Lixin Liu; Zhijia Liu*; Yongming Chen* Exploring the Effect of Amphiphile Architecture on Intracellular Protein Delivery Capacity: Dimeric versus Trimeric Amphiphiles. ACS Applied Materials & Interface 2023, 15, 26328–26339.
10 Zhicheng Le; Zepeng He; Hong Liu; Jia Ke; Lixin Liu; Zhijia Liu*; Yongming Chen* Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases. Biomaterials Science 2022, 10, 4156–4169.
11 Zhicheng Le; Zepeng He; Hong Liu; Lixin Liu; Zhijia Liu*; Yongming Chen* Antioxidant enzymes sequestered within lipid–polymer hybrid nanoparticles for the local treatment of inflammatory bowel disease. ACS Applied Materials & Interface 2021, 13, 55966–55977.
12 Pengfei Zhao#; Zhicheng Le#; Lixin Liu*; Yongming Chen* Therapeutic Delivery to the Brain via the Lymphatic Vasculature. Nano Letters 2020, 20, 5415–5420.
13 Zhicheng Le; Tong Xiao; Zhijia Liu*; Xingliang Liu; Hong Liu; Lixin Liu; Yongming Chen* Combinatorial Synthesis of Redox-Responsive Cationic Polypeptoids for Intracellular Protein Delivery Application. Science China Chemistry 2020, 63, 1619–1625.
14 Zhicheng Le; Zhijia Liu*; Lilong Sun; Lixin Liu; Yongming Chen* Augmenting Therapeutic Potential of Polyphenols by Hydrogen-Bonding Complexation for the Treatment of Acute Lung Inflammation. ACS Applied Bio Materials 2020, 3, 5202–5212.
15 Zhicheng Le; Yantao Chen; Honghua Han; Houkuan Tian; Pengfei Zhao; Chengbiao Yang; Zhiyu He; Lixin Liu; Kam W. Leong; Hai-Quan Mao; Zhijia Liu*; Yongming Chen* Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy. ACS Applied Materials & Interfaces 2018, 10, 42186–42197.
荣誉奖项（Awards）
1.2024.12.12, IFMBE Young Investigators Award at the 18th International Conference on Biomedical Engineering (ICBME 2024), Singapore.
2.2024.12.06, International Travel Award at the 15th BSRT Symposium 2024, Berlin, Germany
招聘与招生（Join Us）
课题组长期招聘具有化学、材料、生物、医学和药学相关背景的特聘副研究员及博士后；欢迎报考课题组硕士和博士研究生；欢迎本科生加入课题组开展科研训练和毕业设计。
