赵奕
个人基本信息
姓名（Name）：赵奕（Yi Zhao）
职称（Title）：副教授/硕士生导师（Associate Professor）
电子邮箱（E-mail）：zhaoy529@mail.sysu.edu.cn
工作经历
2021.11-至今：中山大学，生物医学工程学院，“百人计划”副教授
2018.09-2021.09：美国威斯康星大学麦迪逊分校，生物医学工程学院，博士后
教育经历
2013.09-2018.06：中国药科大学，药剂学，理学博士
2009.09-2013.06：中国药科大学，药物制剂，理学学士
研究方向
1. 器官损伤性疾病的治疗：构建功能性药物递送系统用于脓毒症及多种器官损伤性疾病的治疗以及分子、细胞、动物水平的机制和疗效研究。
2. 治疗感染性疾病的纳米药物：开发生物相容、生物可降解的功能性聚合物系统，克服细菌耐药性，维持体内免疫稳态和循环系统的正常功能，治疗耐药细菌感染及其引发的炎症和并发症。
3. 仿生型药物递送系统用于心脑血管疾病的治疗：基于心脑血管疾病的病理生理学特征，构建仿生型药物输送体系用于药物的靶向递送和控制释放，发挥载体和药物的协同增效作用。
科研项目
1. 广东省重大人才计划青年拔尖人才，2024-2027，主持
2. 广东省基础与应用基础研究自然科学基金面上项目，2025-2027，主持
3. 深圳市基础研究专项自然科学基金面上项目，2024-2027，主持
4. 深圳市医学研究专项资金青年项目，2024-2026，主持
5. 国家自然科学基金青年项目，2023-2025，主持
6. 中山大学“百人计划”引进人才启动经费，2022-2024，主持
兼职与服务
广东省生物医学工程学会生物医用材料与临床应用分会常务委员
担任“广东省自然医学研究会干细胞与中医再生医学专业委员会常务委员
Chinese Chemical Letters青年编委会委员
论著成果
代表性论文（*为通讯作者，#为同等贡献作者）：
目前累计发表SCI论文40余篇，其中以第一作者或通讯作者在Nature Nanotechnology、Advanced Materials、Nano Today、Chemical Engineering Journal、Journal of Controlled Release、Small Methods、ACS Applied Materials & Interfaces、Nano Research等SCI期刊发表论文20余篇。
[1] Mingzhou Ye#, Yi Zhao#, Yuyuan Wang, Ruosen Xie, Yao Tong, John-Demian Sauer, Shaoqin Gong*. NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis. Nature Nanotechnology, 2022, 17(8): 880-890. IF: 40.523
[2] Huayu Fu#, Yanhui Wang#, Bangqi Huang, Zonghao Liang, Yumin Li, Zong Cao*, Jun Wu*, Yi Zhao*. Tannic acid-cerium nanoenzymes serve as broad-spectrum antioxidants to alleviate acute kidney injury by modulating macrophage polarization, mitophagy and endoplasmic reticulum stress. Journal of controlled release, 2025, 380: 892-909. IF: 10.5
[3] Yanhui Wang#, Huayu Fu#, Bangqi Huang, Ziyang Liang, Yijun Shen, Yulan Wang, Jun Wu*, Yi Zhao*. Hollow mesoporous Prussian blue nanoenzymes as Rapamycin carrier for targeted treatment of ischemia/reperfusion-induced acute kidney injury through pro-mitophagy and oxidative stress alleviation. Chemical Engineering Journal, 2024, 497, 155684. IF: 13.4
[4] Wenfeng Lv#, Yanhui Wang#, Huayu Fu, Ziyang Liang, Bangqi Huang, Ruiqin Jiang, Jun Wu*, Yi Zhao*. Recent advances of multifunctional zwitterionic polymers for biomedical application, Acta Biomaterialia, 2024, 181: 19-45. IF: 9.4
[5] Chunlei Dai, Liying Wang, Xinru You, Yi Zhao*, Zhong Cao*, Jun Wu*. Coffee-derived self-anti-inflammatory polymer as drug nanocarrier for enhanced rheumatoid arthritis treatment[J]. Chinese Chemical Letters, 2024, 109869. IF: 9.4
[6] Yunfen Gao#, Liying Wang#, Chufan Zhou, Yi Zhao*, Hai Huang*, Jun Wu*. Low-dimensional antimicrobial nanomaterials in anti-infection treatment and wound healing[J]. Chinese Chemical Letters, 2024, 110028. IF: 9.4
[7] Chunlin Huang#, Zhen Zhang#, Yifei Fang, Keqing Huang, Yi Zhao*, Hai Huang*, Jun Wu*. Cost-effective and natural-inspired lotus root/GelMA scaffolds enhanced wound healing via ROS scavenging, angiogenesis and reepithelialization[J]. International Journal of Biological Macromolecules, 2024, 134496. IF: 7.7
[8] Qi Zong#, Haolin Chen#, Yi Zhao*, Jinming Wang*, Jun Wu*. Bioactive carbon dots for tissue engineering applications. Smart Materials in Medicine, 2024, 5(1): 1-14.
[9] Yifei Fang, Guangze Li, Chunlin Huang, Keqing Huang, Yi Zhao*, Tianqi Nie*, Jun Wu*. Tomato based gelatin methacryloyl hydrogel as an effective natural and low-cost scaffold for accelerative wound healing. International Journal of Biological Macromolecules, 2023, 229, 123-135. IF: 8.025
[10] Jiahui Yan, Yanan Wang, Xinyu Song, Xuefeng Yan, Yi Zhao*, Liangmin Yu, Zhiyu He*. The advancement of gas-generating nanoplatforms in biomedical fields: Current frontiers and future perspectives. Small Methods, 2022, 2200139. IF: 15.367
[11] Yanhui Wang, Zonghao Liang, Ziyang Liang, Wenfeng Lv, Min Chen, Yi Zhao*. Advancements of Prussian blue-based nanoplatforms in biomedical fields: Progress and perspectives. Journal of Controlled Release, 2022, 351, 752-778. IF: 11.467
[12] Qidong Wei#, Dingshi Xu#, Tianyu Li, Xuehan He, Jiasi Wang*, Yi Zhao*, Lei Chen*. Recent Advances of NIR-II Emissive Semiconducting Polymer Dots for In Vivo Tumor Fluorescence Imaging and Theranostics. Biosensors, 2022, 12(12): 1126. IF: 5.743
[13] Mingzhou Ye#, Yi Zhao#, Yuyuan Wang, Miao Zhao, Nisakorn Yodsanit, Ruosen Xie, David Andes, Shaoqin Gong*. A dual-responsive antibiotic-loaded nanoparticle specifically binds pathogens and overcomes antimicrobial-resistant infections. Advanced Materials, 2021, 33(9), 2006772. IF: 32.086
[14] Yi Zhao#, Takuro Shirasu#, Nisakorn Yodsanit, Eric Kent, Mingzhou Ye, Yuyuan Wang, Ruosen Xie, Alexander Christopher Gregg, Yitao Huang, K Craig Kent*, Lian-Wang Guo*, Shaoqin Gong*, Bowen Wang*. Biomimetic, ROS-detonable nanoclusters — A multimodal nanoplatform for anti-restenotic therapy. Journal of Controlled Release, 2021, 338, 295-306. IF: 11.467
[15] Yi Zhao#, Mingju Pu#, Yanan Wang, Liangmin Yu*, Xinyu Song, Zhiyu He*. Application of nanotechnology in acute kidney injury: From diagnosis to therapeutic implications. Journal of Controlled Release, 2021, 336, 233-251. IF: 11.467
[16] Yi Zhao#, Long Cheng#, Yanan Wang#, Xinyu Song, Keyang Li, Xuefeng Yan, Liangmin Yu*, Zhiyu He*. Nanomaterial-based Strategies in Antimicrobial Applications: Progress and Perspectives. Nano Research, 2021, 14(12), 4417-4441. IF: 10.269
[17] Yi Zhao#, Mingju Pu#, Jingwen Zhang, Yanan Wang, Xuefeng Yan, Liangmin Yu*, Zhiyu He*. Recent advancements of nanomaterial-based therapeutic strategies toward sepsis: bacterial eradication, anti-inflammation, and immunomodulation. Nanoscale, 2021, 13(24), 10726-10747. IF: 8.307
[18] Yi Zhao, Ruosen Xie, Nisakorn Yodsanit, Mingzhou Ye, Yuyuan Wang, Bowen Wang, Lian-Wang Guo, K. Craig Kent, Shaoqin Gong*. Hydrogen peroxide-responsive platelet membrane-coated nanoparticles for thrombus therapy. Biomaterials Science, 2021, 9, 2696-2708. IF: 7.59
[19] Yi Zhao, Ruosen Xie, Nisakorn Yodsanit, Mingzhou Ye, Yuyuan Wang, Shaoqin Gong*. Biomimetic fibrin-targeted and H2O2-responsive nanocarriers for thrombus therapy. Nano Today, 2020, 35, 100986. IF: 18.962
[20] Zailin Fu#, Qiaomei Fan#, Yang Zhou, Yi Zhao*, and Zhiyu He*. Elimination of intracellular calcium overload by BAPTA-AM-loaded liposomes: A promising therapeutic agent for acute liver failure. ACS Applied Materials & Interfaces, 2019,11, 39574-39585. IF: 10.383
[21] Yi Zhao, Hai Gao, Jianhua He, Cuiping Jiang, Jing Lu, Wenli Zhang, Hu Yang*, Jianping Liu*. Co-delivery of LOX-1 siRNA and statin to endothelial cells and macrophages in the atherosclerotic lesions by a dual-targeting core-shell nanoplatform: A dual cell therapy to regress plaques. Journal of Controlled Release, 2018, 283, 241-260. IF: 11.467
[22] Yi Zhao#, Zhiyu He#, Hai Gao, Haoyu Tang, Jianhua He, Qing Guo, Wenli Zhang*, and Jianping Liu*. Fine tuning of core-shell structure of hyaluronic acid/cell-penetrating peptides/siRNA nanoparticles for enhanced gene delivery to macrophages in anti-atherosclerotic therapy. Biomacromolecules, 2018, 19, 2944-2956. IF: 6.978
[23] Yi Zhao, Cuiping Jiang, Jianhua He, Qing Guo, Jing Lu, Yun Yang, Wenli Zhang*, Jianping Liu*. Multifunctional dextran sulfate-coated reconstituted high density lipoproteins target macrophages and promote beneficial antiatherosclerotic mechanisms. Bioconjugate Chemistry, 2017, 28, 438-448. IF: 6.069
专利：
[1] 赵奕,汪炎辉,傅华宇.一种负载雷帕霉素的靶向中空介孔普鲁士蓝纳米粒子及其制备方法和在治疗缺血再灌注诱导的急性肾损伤中的应用,2024.08.22, 中国, （CN119236101A）.
[2] 赵奕,傅华宇,汪炎辉.一种单宁酸铈纳米酶的制备方法及其在治疗急性肾损伤中的应用,2024.12.09, 中国, （专利号：202411795814.9）.
[3] Shaoqin Gong, Mingzhou Ye, Yi Zhao, NAD(H) nanoparticles and methods of use. 2023, U.S. Patent, US20230032473A1.
[4] K Craig Kent, Lian-Wang Guo, Bowen Wang, Takuro Shirasu, Shaoqin Gong, Yi Zhao, Biomimetic, reactive oxygen species-detonable nanoclusters for antirestenotic therapy. 2023, PCT, WO2023004387A1.
招聘与招生
博士后招聘
要求：具有生物医学工程、药学、医学、材料学、细胞与分子生物学、免疫学、细胞工程等相关专业背景，获得或即将获得博士学位；有较强的独立科研能力和中英文表达能力，以第一作者在国际知名SCI期刊上发表过研究型论文。
待遇：大学+课题组补助税前约为27万元；符合省在站博士后每人总额30万元生活补贴资助条件的，市财政给予每人12万元在站生活补助，其他人员市财政给予每人36万元在站生活补助；其他配套政策：（1）博士后人员留深工作，深圳市对出站博士后给予36万元生活补助（详情见深圳市博士后出站补贴政策），（2）博士后人员可自愿选择落户深圳市，享受落户补贴3万元（详情见深圳市相关政策）：https://www.sz.gov.cn/zfgb/2024/gb1350/content/post_11719657.html
硕士生招收及本科生训练
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