Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photo- dynamic therapy
Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photo- dynamic therapy
Chen, W. D.; Zhao, J. K.; Hou, M. F.; Yang, M.; Yi, C. Q*
Nanoscale, 2021, 13, 16197-16206
?https://doi.org/10.1039/D1NR04489C
Abstract. Nanotheranostics for fluorescence/magnetic resonance (FL/MR) dual-modal imaging guided photodynamic therapy (PDT) are highly desirable in precision and personalized medicine. In this study, a facile non-covalent electrostatic interaction induced self-assembly strategy is developed to effectively encapsulate gadolinium porphyrin (Gd-TCPP) into homogeneous supramolecular nanoparticles (referred to as Gd-PNPs). Gd-PNPs exhibit the following advantages: (1) excellent FL imaging property, high longitudinal relaxivity (16.157 mM−1 s−1), and good singlet oxygen (1O2) production property; (2) excellent long-term colloidal stability, dispersity and biocompatibility; and (3) enhanced in vivo FL/MR imaging guided tumor growth inhibition efficiency for CT 26 tumor-bearing mice. This study provides a new strategy to design and synthesize metalloporphyrin-based nanotheranostics for imaging-guided cancer therapy with enhanced theranostic properties.